http://www.cnr.it/ontology/cnr/individuo/prodotto/ID228733
Changes in neuroactive steroid secretion associated with CO2-induced panic attacks in normal individuals (Articolo in rivista)
- Type
- Label
- Changes in neuroactive steroid secretion associated with CO2-induced panic attacks in normal individuals (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.psyneuen.2013.04.008 (literal)
- Alternative label
Brambilla F., Perini G., Serra M., Pisu M.G., Zanone S., Toffanin T., Milleri S., Garcia C.S., Biggio G. (2013)
Changes in neuroactive steroid secretion associated with CO2-induced panic attacks in normal individuals
in Psychoneuroendocrinology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Brambilla F., Perini G., Serra M., Pisu M.G., Zanone S., Toffanin T., Milleri S., Garcia C.S., Biggio G. (literal)
- Pagina inizio
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.sciencedirect.com/science/article/pii/S0306453013001261 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- UNIVERSITA' DEGLI STUDI DI CAGLIARI (literal)
- Titolo
- Changes in neuroactive steroid secretion associated with CO2-induced panic attacks in normal individuals (literal)
- Abstract
- Neuroactive
steroids
modulate
anxiety
in
experimental
animals
and
possibly
in
humans.
The
secretion
of
these
compounds
has
been
found
to
be
altered
in
panic
disorder
(PD),
with
such
alterations
having
been
suggested
to
be
a
possible
cause
or
effect
of
panic
symptomatology.
Panic-like
attacks
can
be
induced
in
healthy
individuals
by
administration
of
panicogenic
agents
or
by
physical
procedures,
and
we
have
now
measured
the
plasma
concen-
trations
of
neuroactive
steroids
in
such
individuals
before,
during,
and
after
panicogenic
inhala-
tion
of
CO 2 in
order
to
investigate
whether
abnormalities
of
neuroactive
steroid
secretion
might
contribute
to
the
pathogenesis
of
PD.
Fifty-nine
psychologically
and
physically
healthy
subjects,
including
42
women
(11
in
the
follicular
phase
of
the
menstrual
cycle,
14
in
the
luteal
phase,
and
17
taking
contraceptive
pills)
and
17
men,
who
experienced
a
panic-like
attack
on
previous
exposure
to
7%
CO 2 were
again
administered
7%
CO 2 for
20
min.
Thirty-three
of
these
individuals
(responders)
again
experienced
a
panic-like
attack,
whereas
the
remaining
26
subjects
did
not
(nonresponders).
All
subjects
were
examined
with
the
VAS-A
and
PSL-III-R
scales
for
anxiety
and
panic
symptomatology
before
and
after
CO 2 inhalation.
The
plasma
concentrations
of
progester-
one,
3a,5a-tetrahydroprogesterone
(3a,5a-THPROG
=
allopregnanolone),
3a,5a-tetrahydrode-
soxycorticosterone
(3a,5a-THDOC),
dehydroepiandrosterone
(DHEA),
and
cortisol
were
measured
15
min
and
immediately
before
the
onset
of
CO2
administration
as
well
as
immediately,
10,
30,
and
50
min
after
the
end
of
CO 2 inhalation. (literal)
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