In vivo Laser Assisted Microvascular Repair and End-to-End Anastomosis by Means of Indocyanine Green-Infused Chitosan Patches: A Pilot Study (Articolo in rivista)

Type
Label
  • In vivo Laser Assisted Microvascular Repair and End-to-End Anastomosis by Means of Indocyanine Green-Infused Chitosan Patches: A Pilot Study (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/lsm.22145 (literal)
Alternative label
  • Giuseppe Esposito; Francesca Rossi; Paolo Matteini; Alba Scerrati; Alfredo Puca; Alessio Albanese; Giacomo Rossi; Fulvio Ratto; Giulio Maira; Roberto Pini (2013)
    In vivo Laser Assisted Microvascular Repair and End-to-End Anastomosis by Means of Indocyanine Green-Infused Chitosan Patches: A Pilot Study
    in Lasers in surgery and medicine (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Giuseppe Esposito; Francesca Rossi; Paolo Matteini; Alba Scerrati; Alfredo Puca; Alessio Albanese; Giacomo Rossi; Fulvio Ratto; Giulio Maira; Roberto Pini (literal)
Pagina inizio
  • 318 (literal)
Pagina fine
  • 325 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 45 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Note
  • PubMe (literal)
  • Scopu (literal)
  • Google Scholar (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy, 00100 Institute of Applied Physic, Italian National Research Council, Sesto Fiorentino (Florence), Italy, 50019 Faculty of Veterinary Medicine, University of Camerino, Matelica, Italy, 62024 Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland (literal)
Titolo
  • In vivo Laser Assisted Microvascular Repair and End-to-End Anastomosis by Means of Indocyanine Green-Infused Chitosan Patches: A Pilot Study (literal)
Abstract
  • La copertina del volume della rivista in cui è stato pubblicato l'articolo riporta un'immagine dell'articolo stesso. (literal)
  • Background and Objectives: Laser-based repairing techniques offer several advantages respect to standard suturing in microsurgery. In this work we evaluate the applicability and feasibility of two innovative laser-based approaches for microvascular repair and anastomoses: 1) laser-assisted vascular repair (LAVR); 2) laser-assisted end-to-end vascular anastomosis (LAVA). All these procedures have been executed by the use of diode laser irradiation and chitosan-patches infused with Indocyanine Green (ICG). Study Design/Materials and Methods: Experiments were performed on 30 rabbits. 20 animals underwent LAVR and 10 end-to-end LAVA procedure. In the LAVR group, a 5-mm longitudinal cut was performed on the common carotid artery (CCA), then an ICG-infused chitosan patch was topically applied and laser-soldered over the arterial lesion. In the LAVA group the end-to-end anastomosis was executed on CCA by means of application of the 3 interrupted sutures and subsequent laser soldering of the ICG-infused patch. Animals underwent different follow-up periods (2, 7, 30, 90 days). At the end of every follow-up, the animals were re-anesthetized and a microdoppler analysis was performed in order to check patency of the treated vessels. Then soldered segments were excised and subjected to histological and ultrastructural evaluations. Results: At the end of surgery no bleeding from the treated segment was observed; all the treated vessels were patent. At the end of follow-up periods, no signs of perivascular haemorrhage were found. An intraoperative microdoppler evaluation assessed the patency of all the treated vessels. Histology showed a good reorganization of the vascular wall structures an early endothelial regeneration was observed by SEM. Conclusions: Our study demonstrated the efficacy of laser tissue soldering by means of ICG-infused chitosan patches for the in vivo repairing of microvascular lesions and end-to-end anastomoses. This approach offers several advantages over conventional suturing methods and is technically easy to perform, minimizing the surgical trauma to vessels. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it