The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes (Articolo in rivista) (literal)

Anno

• 1987-01-01T00:00:00+01:00 (literal)

Alternative label

• Perlino E, Cortese R, Ciliberto G (1987)
  The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes
  in EMBO journal (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Perlino E, Cortese R, Ciliberto G (literal)

Pagina inizio

• 2767 (literal)

Pagina fine

• 2771 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 6 (literal)

Rivista

• EMBO journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR (literal)

Titolo

• The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes (literal)

Abstract

• In order to investigate the mechanism of expression of the human alpha 1-antitrypsin (alpha 1-AT) gene in macrophages, we have characterized the alpha 1-AT transcriptional units in these cells and discovered that there is a macrophage-specific promoter located approximately 2000 bp upstream of the hepatocyte-specific promoter. Transcription from the two alpha 1-AT promoters is mutually exclusive: the macrophage promoter is silent in hepatocytes and the hepatocyte promoter is silent in macrophages. In addition, in macrophages two distinct mRNAs are generated transcript by alternative splicing. These results suggest that alpha 1-AT gene transcription responds to two different cell-specific regulatory mechanisms. (literal)

Autore CNR

• ELDA PERLINO (Persona)

Insieme di parole chiave

• Parole chiave di "The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ELDA PERLINO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• EMBO journal (Rivista)

Insieme di parole chiave di

• Parole chiave di "The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes" (Insieme di parole chiave)