Synthesis of a novel class of nitrido Tc-99m radiopharmaceuticals with phosphino-thiol ligands showing transient heart uptake (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Synthesis of a novel class of nitrido Tc-99m radiopharmaceuticals with phosphino-thiol ligands showing transient heart uptake (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0969-8051(00)00099-8 (literal)

Alternative label

• Bolzati C.; Uccelli L.; Boschi A.; Malagò E.; Duatti A.; Tisato F.; Refosco F.; Pasqualini R.; Piffanelli A.; (2000)
  Synthesis of a novel class of nitrido Tc-99m radiopharmaceuticals with phosphino-thiol ligands showing transient heart uptake
  in Nuclear medicine and biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bolzati C.; Uccelli L.; Boschi A.; Malagò E.; Duatti A.; Tisato F.; Refosco F.; Pasqualini R.; Piffanelli A.; (literal)

Pagina inizio

• 369 (literal)

Pagina fine

• 374 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0969805100000998 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 27 (literal)

Rivista

• Nuclear medicine and biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1-5,9 Laboratory of Nuclear Medicine, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy / 6,7 ICTIMA, CNR, Padova, Italy / 8 CIS Bio International, Gif-Sur-Yvette, France (literal)

Titolo

• Synthesis of a novel class of nitrido Tc-99m radiopharmaceuticals with phosphino-thiol ligands showing transient heart uptake (literal)

Abstract

• A novel class of technetium-99m radiopharmaceuticals showing high heart uptake is described. These complexes were prepared through a simple and efficient procedure, and their molecular structure fully characterized. They are formed by a terminal Tc?N multiple bond and two bidentate phosphine-thiol ligands [R2P-(CH2)nSH, n = 2, 3] coordinated to the metal ion through the neutral phosphorus atom and the deprotonated thiol sulfur atom. The resulting geometry was trigonal bipyramidal. Biodistribution studies were carried out in rats. The complexes exhibited high initial heart uptake and elimination through liver and kidneys. The washout kinetic from heart was dependent on the nature of the lateral R groups on the phosphine-thiol ligands. When R = phenyl, heart activity was rapidly eliminated within 10-20 min. Instead, when R = tolyl, cyclohexyl, persistent heart uptake was observed. Extraction of activity from myocardium tissue showed that no change of the chemical identity of the tracer occurred after heart uptake. On the contrary, metabolization to more hydrophilic species occurred in liver and kidneys. (literal)

Prodotto di

• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)

Autore CNR

• CRISTINA BOLZATI (Unità di personale interno)
• FRANCESCO TISATO (Persona)
• FIORENZO REFOSCO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Synthesis of a novel class of nitrido Tc-99m radiopharmaceuticals with phosphino-thiol ligands showing transient heart uptake" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)

Autore CNR di

• CRISTINA BOLZATI (Unità di personale interno)
• FRANCESCO TISATO (Persona)
• FIORENZO REFOSCO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nuclear medicine and biology (Rivista)

Insieme di parole chiave di

• Keywords of "Synthesis of a novel class of nitrido Tc-99m radiopharmaceuticals with phosphino-thiol ligands showing transient heart uptake" (Insieme di parole chiave)