Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.metabol.2012.10.002 (literal)

Alternative label

• Knowles, J.W.;Assimes, T.L.;Tsao, P.S.;Natali, A.;Mari, A.;Quertermous, T.;Reaven, G.M.;Abbasi, F. (2013)
  Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp
  in Metabolism, clinical and experimental (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Knowles, J.W.;Assimes, T.L.;Tsao, P.S.;Natali, A.;Mari, A.;Quertermous, T.;Reaven, G.M.;Abbasi, F. (literal)

Pagina inizio

• 548 (literal)

Pagina fine

• 553 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/23151437 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 62 (literal)

Rivista

• Metabolism, clinical and experimental (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 2, 3, 6, 7, 8: Stanford University, Division of Cardiovascular Medicine, Falk CVRC, 300 Pasteur Dr., Stanford, CA 94305-5406, USA ; 4: University of Pisa, Department of Internal Medicine, Via Roma 67, 56100 Pisa, Italy ; 5: Institute of Biomedical Engineering-National Research Council, Corso Stati Uniti 4, 35127 Padova, Italy; (literal)

Titolo

• Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp (literal)

Abstract

• Background. Two direct measurements of peripheral insulin sensitivity are the M value derived from the euglycemic, hyperinsulinemic clamp (EC) and the steady-state plasma glucose (SSPG) concentration derived from the insulin suppression test (IST). Prior work suggests that these measures are highly correlated, but the agreement between them is unknown. To determine the agreement between SSPG andM and to develop transformation equations to convert SSPG to M and vice versa, we directly compared these two measurements in the same individuals. Methods. A total of 15 nondiabetic subjects (9 women and 6 men) underwent both an EC and a modified version of the IST within a median interval of 5 days. We performed standard correlation metrics of the two measures and developed transformation regression equations for the two measures. Results. The mean±SD age of the subjects was 57±7 years and body mass index, 27.7± 3.9 kg/m2. The median (interquartile range) SSPG concentration was 6.7 (5.1, 9.8) mmol/L and M value, 49.6 (28.9, 64.2) ?mol/min/kg-LBM. There was a highly significant correlation between SSPG and M (r=-0.87, P <0.001). The relationship was best fit by regression models with exponential/logarithmic functions (R2=0.85). Bland-Altman plots demonstrated an excellent agreement between these measures of insulin action. Conclusion. The SSPG and M are highly related measures of insulin sensitivity and the results provide the means to directly compare the two measurements. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Institute of biomedical engineering (ISIB) (Istituto)

Autore CNR

• ANDREA MARI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• ANDREA MARI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Metabolism, clinical and experimental (Rivista)

Insieme di parole chiave di

• Keywords of "Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp" (Insieme di parole chiave)