Collagen changes in the ductal infiltrating (scirrhous) carcinoma of the human breast. A possible role played by type I trimer collagen on the invasive growth. (Articolo in rivista)

Type
Label
  • Collagen changes in the ductal infiltrating (scirrhous) carcinoma of the human breast. A possible role played by type I trimer collagen on the invasive growth. (Articolo in rivista) (literal)
Anno
  • 1986-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pucci Minafra, I., Minafra, S., Tomasino, R.M., Sciarrino, S., Tinervia, R. (1986)
    Collagen changes in the ductal infiltrating (scirrhous) carcinoma of the human breast. A possible role played by type I trimer collagen on the invasive growth.
    in Journal of submicroscopic cytology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pucci Minafra, I., Minafra, S., Tomasino, R.M., Sciarrino, S., Tinervia, R. (literal)
Pagina inizio
  • 795 (literal)
Pagina fine
  • 805 (literal)
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  • 18 (literal)
Rivista
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  • 11 (literal)
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  • 4 (literal)
Note
  • PubMe (literal)
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  • Dipartimento di Biologia Cellulare e dello Sviluppo, Istituto di Istologia ed Embriologia, Universirs di Palermo, Via Archirafi 20, 90121 Palermo; * Istituto di Anatomia ed Istologia Patologica, Policlinico di Palermo, Italia (literal)
Titolo
  • Collagen changes in the ductal infiltrating (scirrhous) carcinoma of the human breast. A possible role played by type I trimer collagen on the invasive growth. (literal)
Abstract
  • The tumour stroma in cases of ductal infiltrating carcinoma of the mammary gland contains substantial amounts of collagen type I trimer, besides the regular collagen types. Reconstituted collagen trimer consists of fibrils that are significantly thinner than reconstituted fibrils of type I collagen. The axial periodicity is somewhat longer due to widening of the c-d and d-e regions. Transmission EM of the tumours shows characteristic phenomena at the stromal-tumour cell junctions: frequent absence of a basal lamina and thin disordered collagen fibrils that show frequent direct contacts with tumour cells. On the basis of literature data concerning the interaction between stroma and epithelia under physiological and pathological conditions it is hypothesized that the interaction of collagen type I trimer fibrils with tumour cells is instrumental in augmenting tumour cell progression and that the trimer may provide contact guidance for invasive growth. (literal)
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