Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.neurobiolaging.2012.01.005 (literal)

Alternative label

• Morbelli, S.; Drzezga, A.; Perneczky, R.; Frisoni, G.B.; Caroli, A.; Van Berckel, B.N.M.; Ossenkoeppele, R.; Guedj, E.; Didic, M.; Brugnolo, A.; Sambuceti, G.; Pagani, Marco; Salmon, E.; Nobili, F (2012)
  Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project
  in Neurobiology of aging (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Morbelli, S.; Drzezga, A.; Perneczky, R.; Frisoni, G.B.; Caroli, A.; Van Berckel, B.N.M.; Ossenkoeppele, R.; Guedj, E.; Didic, M.; Brugnolo, A.; Sambuceti, G.; Pagani, Marco; Salmon, E.; Nobili, F (literal)

Pagina inizio

• 2533 (literal)

Pagina fine

• 2550 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• DISCIPLINA DI RIFERIMENTO: Neurology; AREA DI VALUTAZIONE: 06 - Scienze mediche; CODICE PUMA: /cnr.istc/2012-A0-028 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0197458012000218 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• Neurobiology of aging (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 18 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-ISTC, Roma5-Palestro; LENITEM Laboratory of Epidemiology and Neuroimaging - IRCCS S. Giovanni di Dio-FBF, Brescia; Nuclear Medicine Unit, Department of Internal Medicine, San Martino University Hospital, Genoa; Department of Nuclear Medicine, Technische Universität München; Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam;Service Central de Biophysique et de Médecine Nucléaire and Centre Européen de Recherche en Imagerie Médicale (CERIMED); Cognitive and Behavioral Neuroscience Centre, University of Liège, Liège, Belgium; (literal)

Titolo

• Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project (literal)

Abstract

• We explored resting-state metabolic connectivity in prodromal Alzheimer's disease (pAD) patients and in healthy controls (CTR), through a voxel-wise interregional correlation analysis of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) by means of statistical parametric mapping. Baseline 18F-fluorodeoxyglucose-positron emission tomography of 36 patients with amnestic mild cognitive impairment who converted to Alzheimer's disease (AD) dementia after an average time of 2 years (pAD) and of 105 CTR were processed. The area of hypometabolism in pAD showed less metabolic connectivity in patients than in CTR (autocorrelation and correlation with large temporal and frontal areas, respectively). pAD patients showed limited correlation even in selected nonhypometabolic areas, including the hippocampi and the dorsolateral prefrontal cortex (DLFC). On the contrary, in CTR group correlation was highlighted between hippocampi and precuneus/posterior cingulate and frontal cortex, and between dorsolateral prefrontal cortex and caudate nuclei and parietal cortex. The reduced metabolic connections both in hypometabolic and nonhypometabolic areas in pAD patients suggest that metabolic disconnection (reflecting early diaschisis) may antedate remote hypometabolism (early sign of synaptic degeneration) (literal)

Prodotto di

• Neuropatologie e bisogni individuali: diagnostica per immagini, assessment linguistico-cognitivo, counseling genetico e trattamento riabilitativo (ME.P02.015.001) (Modulo)
• Institute of cognitive sciences and technologies (ISTC) (Istituto)

Autore CNR

• MARCO PAGANI (Persona)

Insieme di parole chiave

• Keywords of "Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARCO PAGANI (Persona)

Prodotto

• Institute of cognitive sciences and technologies (ISTC) (Istituto)
• Neuropatologie e bisogni individuali: diagnostica per immagini, assessment linguistico-cognitivo, counseling genetico e trattamento riabilitativo (ME.P02.015.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurobiology of aging (Rivista)

Insieme di parole chiave di

• Keywords of "Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project" (Insieme di parole chiave)