Insulin-dependent diabetes mellitus and malaria in Sardinia. (Abstract/Poster in atti di convegno)

Type
Label
  • Insulin-dependent diabetes mellitus and malaria in Sardinia. (Abstract/Poster in atti di convegno) (literal)
Anno
  • 1996-01-01T00:00:00+01:00 (literal)
Alternative label
  • Bernardinelli L, Fiorani O, Lisa A, Pascutto C, Solinas G, Songini M, Zei G. (1996)
    Insulin-dependent diabetes mellitus and malaria in Sardinia.
    in XLII Congresso dell'Associazione Genetica Italiana, Riccione (RN), 2-5 Ottobre 1996
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bernardinelli L, Fiorani O, Lisa A, Pascutto C, Solinas G, Songini M, Zei G. (literal)
Pagina inizio
  • 9 (literal)
Pagina fine
  • 10 (literal)
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  • Atti Associazione Genetica Italiana (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • XLII (literal)
Note
  • Poster (literal)
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  • Dipartimento di Science Sanitarie Applieate e Psicocomporramentaii, Universita di Pavia; IGM-CNR, Pavia; Istiluto di Igiene, Universita di Sassari; 4Centro di Malattie Dismetaboliche, Ospedale S, Michele, Cagliari. (literal)
Titolo
  • Insulin-dependent diabetes mellitus and malaria in Sardinia. (literal)
Abstract
  • Studies on the genetic component of insulin-dependent diabetes mellitus (IDDM) showed association of the disease with HLA antigens, some of which confer susceptibility to IDDM, while others confer resistance, Moreover, studies in West Africa demonstrated that an HLA class I antigen and an HLA class II haplotype are associated with a reduced susceptibility to severe malaria. Sardinia, having one of the highest incidence of IDDM in the world, particular frequency distributions of HLA alleles linked to IDDM development , and a long history of malaria characterizing with different intensity different areas of the island, offers the opportunity to search for the mechanisms underlying the association between HLA antigens, malaria and IDDM. In this study the geographical variation of IDDM risk according to the degree of malarial morbidity is analyzed using two different sets of data: a) the cumulative IDDM prevalence among the army conscripts born in Sardinia between 1936 and 1973, and b) the IDDM incidence for the residents in the Sardinian communes aged 0-29 between 1989 and 1992, coming from the EURODIAB Register. Particular attention was paid to assign each commune of the island a reliable degree of malaria morbidity. To this end the information coming from different sources concerning the history of malaria and its intensity for each area, along with ecological and geographical characteristics of the communes (at the time in which malaria was endemic) probably controlling the presence of the vector of the P, falciparum, were recorded. We selected two sets of communes showing respectively a high degree and a low degree of malaria morbidity and we re-analyzed historical data concerning IDDM army conscripts resident in the communes comprised in each of the two sets. The results demonstrated that the increase over time of has an analogous trend in both groups, while constantly showing lower values in the group having a high level of malaria morbidity. Similar results are obtained when the association between genetic selection operated by malaria and present IDDM relative risk (RR) in the Sardinian communes is investigated. (literal)
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