Endoplasmic reticulum stress is activated in endometrial adenocarcinoma. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Endoplasmic reticulum stress is activated in endometrial adenocarcinoma. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Bifulco G, Miele C, Di Jeso B, Beguinot F, Nappi C, Di Carlo C, Capuozzo S, Terrazzano G, Insabato L, Ulianich L. (2012)
  Endoplasmic reticulum stress is activated in endometrial adenocarcinoma.
  in Gynecologic oncology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bifulco G, Miele C, Di Jeso B, Beguinot F, Nappi C, Di Carlo C, Capuozzo S, Terrazzano G, Insabato L, Ulianich L. (literal)

Rivista

• Gynecologic oncology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Via Pansini 5, 80131 Napoli, Italy. Department of Obstetrics and Gynecology, University Federico II, Naples, Italy. giuseppe.bifulco@unina.it (literal)

Titolo

• Endoplasmic reticulum stress is activated in endometrial adenocarcinoma. (literal)

Abstract

• OBJECTIVES: Endometrial cancer is the most common malignancy of the female genital tract. However, in spite of a huge advance in our understanding of endometrial cancer biology, therapeutic modalities haven't significantly changed over the past 40years. The activation of the Unfolded Protein Response (UPR) and GRP78 increase following Endoplasmic Reticulum (ER) stress have been recently identified as mechanisms favoring growth, invasion and resistance to therapy of different types of cancer. However, a possible role of ER stress and GRP78 in endometrial cancer has never been investigated. METHODS: Tissue specimens from normal and neoplastic endometrium were analyzed for the expression of the ER stress markers GRP78, ATF6 and CHOP by Real-Time RT-PCR. In addition, GRP78 protein expression and localization were evaluated by Western Blot and immunohistochemistry, respectively. The effect of GRP78 knock down on cell growth of Ishikawa cells was analyzed by proliferation curves analysis. RESULTS: In this analisys, the expression levels of GRP78, ATF6 and CHOP mRNAs were significantly increased in specimens of endometrioid endometrial carcinomas. GRP78 and ATF6 protein expression levels were also increased in specimens of endometrial adenocarcinomas. GRP78 knock down caused a decrease of Ishikawa cells growth. CONCLUSIONS: The increased expression of ER stress markers in endometrioid endometrial carcinomas suggests a role for ER stress, the UPR and, possibly, GRP78 in endometrial cancer. Whether this mechanisms have a substantial function in the pathogenesis of malignant transformation of human endometrium is still under investigation in our laboratory. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002) (Modulo)

Autore CNR

• TIRO CLAUDIO NAPPI (Persona)
• BRUNO DI JESO (Unità di personale interno)
• LUCA ULIANICH (Unità di personale interno)
• FRANCESCO BEGUINOT (Unità di personale esterno)
• CLAUDIA MIELE (Persona)

Incoming links:

Autore CNR di

• FRANCESCO BEGUINOT (Unità di personale esterno)
• CLAUDIA MIELE (Persona)
• LUCA ULIANICH (Unità di personale interno)
• TIRO CLAUDIO NAPPI (Persona)
• BRUNO DI JESO (Unità di personale interno)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Gynecologic oncology (Rivista)