Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation. (Articolo in rivista)

Type
Label
  • Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1186/1471-2148-10-351 (literal)
Alternative label
  • Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S. (2010)
    Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation.
    in BMC evolutionary biology (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 10 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 12 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • SCImago (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Universit di Napoli Federico II, Universit di Salerno, Naples, Italy Dipartimento di Scienze Fisiche, Universit Degli Studi di Napoli Federico II, Naples, Italy Istituto Nazionale di Fisica Nucleare - Sezione di Napoli, Naples, Italy Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Universit Degli Studi di Napoli Federico II, Naples, Italy IEOS Istituto di Endocrinologia Ed Oncologia Sperimentale, CNR Napoli, Naples, Italy (literal)
Titolo
  • Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation. (literal)
Abstract
  • BACKGROUND: Many natural phenomena are directly or indirectly related to latitude. Living at different latitudes, indeed, has its consequences with being exposed to different climates, diets, light/dark cycles, etc. In humans, one of the best known examples of genetic traits following a latitudinal gradient is skin pigmentation. Nevertheless, also several diseases show latitudinal clinals such as hypertension, cancer, dismetabolic conditions, schizophrenia, Parkinson's disease and many more. RESULTS: We investigated, for the first time on a wide genomic scale, the latitude-driven adaptation phenomena. In particular, we selected a set of genes showing signs of latitude-dependent population differentiation. The biological characterization of these genes showed enrichment for neural-related processes. In light of this, we investigated whether genes associated to neuropsychiatric diseases were enriched by Latitude-Related Genes (LRGs). We found a strong enrichment of LRGs in the set of genes associated to schizophrenia. In an attempt to try to explain this possible link between latitude and schizophrenia, we investigated their associations with vitamin D. We found in a set of vitamin D related genes a significant enrichment of both LRGs and of genes involved in schizophrenia. CONCLUSIONS: Our results suggest a latitude-driven adaptation for both schizophrenia and vitamin D related genes. In addition we confirm, at a molecular level, the link between schizophrenia and vitamin D. Finally, we discuss a model in which schizophrenia is, at least partly, a maladaptive by-product of latitude dependent adaptive changes in vitamin D metabolism. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it