CpG islands undermethylation in human genomic regions under selective pressure. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• CpG islands undermethylation in human genomic regions under selective pressure. (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pone.0023156 (literal)

Alternative label

• Cocozza S, Akhtar MM, Miele G, MONTICELLI A. (2011)
  CpG islands undermethylation in human genomic regions under selective pressure.
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cocozza S, Akhtar MM, Miele G, MONTICELLI A. (literal)

Rivista

• PloS one (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• SCImago (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II, Università di Salerno, Naples, Italy Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Università degli Studi di Napoli Federico II, Naples, Italy Dipartimento di Scienze Fisiche, Università degli Studi di Napoli Federico II, Naples, Italy Istituto Nazionale di Fisica Nucleare - Sezione di Napoli, Naples, Italy Istituto di Endocrinologia ed Oncologia Sperimentale, IEOS CNR Napoli, Naples, Italy (literal)

Titolo

• CpG islands undermethylation in human genomic regions under selective pressure. (literal)

Abstract

• DNA methylation at CpG islands (CGIs) is one of the most intensively studied epigenetic mechanisms. It is fundamental for cellular differentiation and control of transcriptional potential. DNA methylation is involved also in several processes that are central to evolutionary biology, including phenotypic plasticity and evolvability. In this study, we explored the relationship between CpG islands methylation and signatures of selective pressure in Homo Sapiens, using a computational biology approach. By analyzing methylation data of 25 cell lines from the Encyclopedia of DNA Elements (ENCODE) Consortium, we compared the DNA methylation of CpG islands in genomic regions under selective pressure with the methylation of CpG islands in the remaining part of the genome. To define genomic regions under selective pressure, we used three different methods, each oriented to provide distinct information about selective events. Independently of the method and of the cell type used, we found evidences of undermethylation of CGIs in human genomic regions under selective pressure. Additionally, by analyzing SNP frequency in CpG islands, we demonstrated that CpG islands in regions under selective pressure show lower genetic variation. Our findings suggest that the CpG islands in regions under selective pressure seem to be somehow more \"protected\" from methylation when compared with other regions of the genome. (literal)

Prodotto di

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)
• Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002) (Modulo)

Autore CNR

• ANTONELLA MONTICELLI (Unità di personale interno)

Incoming links:

Autore CNR di

• ANTONELLA MONTICELLI (Unità di personale interno)

Prodotto

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)
• Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)