Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts (Articolo in rivista)

Type
Label
  • Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts (Articolo in rivista) (literal)
Anno
  • 1998-01-01T00:00:00+01:00 (literal)
Alternative label
  • Monica Fedele 1,2, Maria Teresa Berlingieri 2, Stefania Scala 1, Lorenzo Chiariotti 2, Giuseppe Viglietto 1, Volkhard Rippel 3, Jorn Bullerdiek 3, Massimo Santoro 2 and Alfredo Fusco 4 (1998)
    Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts
    in Oncogene (Basingstoke)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Monica Fedele 1,2, Maria Teresa Berlingieri 2, Stefania Scala 1, Lorenzo Chiariotti 2, Giuseppe Viglietto 1, Volkhard Rippel 3, Jorn Bullerdiek 3, Massimo Santoro 2 and Alfredo Fusco 4 (literal)
Pagina inizio
  • 413 (literal)
Pagina fine
  • 418 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 17 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, via M. Semmola, 80131 Naples, Italy; 2Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, FacoltaÁ di Medicina e Chirurgia di Napoli, UniversitaÁ degli Studi di Napoli `Federico II', via Pansini, 5, 80131 Naples, Italy; 3Center for Human Genetics and Genetic Counseling, University of Bremen, Leobenerstr, ZHG, Bremen, Germany; 4Dipartimento di Medicina Sperimentale e Clinical FacoltaÁ di Medicina e Chirurgia di Catanzaro, UniversitaÁ di Reggio Calabria, via Tommaso Campanella, 88100 Catanzaro, Italy (literal)
Titolo
  • Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts (literal)
Abstract
  • Overexpression of the high mobility group I (HMGI) proteins is often associated with the malignant pheno- type. Moreover, many benign human tumors, mainly of mesenchymal origin, are characterized by rearrange- ments of the HMGI-C gene. In most cases, HMGI-C alterations involve breaks within the third intron of the gene resulting in aberrant transcripts carrying exons from 1 ± 3, which encode the three DNA binding domains, fused to ectopic sequences. Here, we show that the expression of a truncated form of HMGI-C protein carrying only the three DNA-binding domains, or of a fusion protein carrying the three DNA-binding domains of HMGI-C and the LIM domains of the lipoma preferred partner gene (LPP) protein, causes malignant transformation of NIH3T3 cells. The unrearranged wild- type HMGI-C cDNA did not exert any transforming activity. These ®ndings indicate that rearranged forms of HMGI-C play a role in cell transformation. (literal)
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