Involvement of the HMGI(Y) Gene in a Microfollicular Adenoma of the Thyroid (Articolo in rivista)

Type
Label
  • Involvement of the HMGI(Y) Gene in a Microfollicular Adenoma of the Thyroid (Articolo in rivista) (literal)
Anno
  • 1999-01-01T00:00:00+01:00 (literal)
Alternative label
  • Paola Dal Cin,1 Alfredo Fusco,2 Gazanfer Belge,3 Gennaro Chiappetta,4 Monica Fedele,5 Patrick Pauwels,6 Jo¨ rn Bullerdiek,3 and Herman Van den Berghe1 (1999)
    Involvement of the HMGI(Y) Gene in a Microfollicular Adenoma of the Thyroid
    in Genes chromosomes & cancer (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Paola Dal Cin,1 Alfredo Fusco,2 Gazanfer Belge,3 Gennaro Chiappetta,4 Monica Fedele,5 Patrick Pauwels,6 Jo¨ rn Bullerdiek,3 and Herman Van den Berghe1 (literal)
Pagina inizio
  • 286 (literal)
Pagina fine
  • 289 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 24 (literal)
Rivista
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  • 1Center for Human Genetics, University of Leuven, Leuven, Belgium 2Dipartimento di Medicina Sperimentale e Clinica, Facolta` di Medicina e Chirurgia di Catanzaro, Universita` di Catanzaro, Catanzaro, Italy 3Center for Human Genetics and Genetic Counseling, University of Bremen, Bremen, Germany 4Istituto Nazionale die Tumori di Napoli, Fondazione Senatore Pascale, Naples, Italy 5Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare and Facolta` di Medicina e Chirurgia, Universita` di Napoli ''Federico II'', Naples, Italy 6Department of Pathology, Stichting PAMM, Catharina Ziekenhuis, Eindhoven, the Netherlands (literal)
Titolo
  • Involvement of the HMGI(Y) Gene in a Microfollicular Adenoma of the Thyroid (literal)
Abstract
  • Follicular thyroid adenomas are epithelial tumors characterized by subgroups with specific chromosomal aberrations. Here we present a case with translocation t(1;6)(p35;p21). In 1p35 and 6p21, two genes of the high-mobility group of proteins are located. With P1-derived Artificial Chromosome (PACs) derived from the HMG17 gene located at 1p35 and HMGI(Y) located at 6p21, fluorescence in situ hybridization was performed. The breakpoints were located distal to HMG17 and proximal to HMGI(Y), but no rearrangement of the genes was shown by FISH. However, an overexpression of the HMGI(Y) gene was detected by RT-PCR as well as by immunohistochemistry techniques. This suggests a breakpoint in the proximity of the HMGI(Y) deregulating HMGI(Y) gene expression, a situation found in a variety of human benign mesenchymal tumors with involvement of chromosome band 6p21. (literal)
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