Regulation of thymosin b10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes (Articolo in rivista)

Type
Label
  • Regulation of thymosin b10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes (Articolo in rivista) (literal)
Anno
  • 1999-01-01T00:00:00+01:00 (literal)
Alternative label
  • Giuseppe Viglietto, Daniela Califano, Paola Bruni, Gustavo Baldassarre, Maria Teresa Vento, Barbara Belletti, Monica Fedele, Giovanni Santelli, Angelo Boccia, Giovanni Manzo, Massimo Santoro and Alfredo Fusco (1999)
    Regulation of thymosin b10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes
    in European journal of endocrinology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Giuseppe Viglietto, Daniela Califano, Paola Bruni, Gustavo Baldassarre, Maria Teresa Vento, Barbara Belletti, Monica Fedele, Giovanni Santelli, Angelo Boccia, Giovanni Manzo, Massimo Santoro and Alfredo Fusco (literal)
Pagina inizio
  • 597 (literal)
Pagina fine
  • 607 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 140 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Via M. Semmola, 80131 Napoli, Italy, Dipartimento di Medicina Sperimentale e Clinica, Facolta` di Medicina e Chirurgia di Catanzaro, Universita` di Reggio Calabria, via Tommaso Campanella, 88100 Catanzaro, Italy Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta` di Medicina e Chirurgia di Napoli, Universita` degli Studi di Napoli 'Federico II', via Pansini, 5, 80131 Napoli, Italia (literal)
Titolo
  • Regulation of thymosin b10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes (literal)
Abstract
  • Objective: To investigate the expression of thymosin b10 - a small conserved acidic protein involved in the inhibition of actin polymerization - in human and experimental thyroid goiters as well as the regulation exerted by TSH on thymosin b10 expression in thyroid follicular cells both in vivo and in vitro. Design: To this aim, we have used 5 bioptic specimens from patients affected by thyroid goiter, a well known experimental model of thyroid goitrogenesis (rat fed with the drug propylthiouracil) and a cultured rat thyroid cell line (PC Cl 3 cells) as a model system. Results:We report that the mRNA expression of thymosin b10 is markedly enhanced in human goiters compared with normal thyroid. In vivo results showed that the steady-state level of thymosin b10 mRNA is up-regulated in the thyroid gland of propylthiouracil-fed rats in parallel with follicular cell proliferation: iodide administration to goitrous rats, which induced a marked involution of thyroid hyperplasia, reduced the mRNA level of thymosin b10. Finally, in vitro studies showed that in cultured rat thyrocytes, the expression of thymosin b10 mRNA is induced in a time- and dose-dependent manner by the activation of pathways which are mitogenic for thyroid cells (i.e. the protein kinase (PK) A and PKC pathways). Conclusion: Taken together, the findings reported here demonstrate that thymosin b10 expression is regulated by extracellular signals that stimulate growth of thyroid cells both in vitro and in vivo, and suggest a role for this protein in thyroid diseases characterized by proliferation of follicular cells. (literal)
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