Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Alternative label

• Stefania Scala*, Giuseppe Portella*, Monica Fedele*, Gennaro Chiappetta+, and Alfredo Fusco?§ (2000)
  Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias
  in Proceedings of the National Academy of Sciences of the United States of America
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Stefania Scala*, Giuseppe Portella*, Monica Fedele*, Gennaro Chiappetta+, and Alfredo Fusco?§ (literal)

Pagina inizio

• 4256 (literal)

Pagina fine

• 4261 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 97 (literal)

Rivista

• Proceedings of the National Academy of Sciences of the United States of America (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• *Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche cyo Dipartimento di Patologia Cellulare e Molecolare, Facolta` di Medicina e Chirurgia, Universita` degli Studi di Napoli, 80131 Naples, Italy; +Istituto Nazionale dei Tumori Fondazione Senatore Pascale, via M. Semmola, 80131 Naples, Italy; and ?Dipartimento di Medicina Sperimentale e Clinica, Facolta` di Medicina e Chirurgia di Catanzaro, Universita` degli Studi di Catanzaro, via Tommaso Campanella 5, 88100 Catanzaro, Italy (literal)

Titolo

• Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias (literal)

Abstract

• High mobility group I (HMGI) proteins are overexpressed in several human malignant tumors. We previously demonstrated that inhibition of HMGI synthesis prevents thyroid cell transformation. Here, we report that an adenovirus carrying the HMGI(Y) gene in an antisense orientation (Ad-Yas) induced programmed cell death of two human thyroid anaplastic carcinoma cell lines (ARO and FB-1), but not normal thyroid cells. The Ad-Yas virus led to death of lung, colon, and breast carcinoma cells. A control adenovirus carrying the lacZ gene did not inhibit the growth of either normal or neoplastic cells. Ad-Yas treatment of tumors induced in athymic mice by ARO cells caused a drastic reduction in tumor size. Therefore, suppression of HMGI(Y) protein synthesis by an HMGI(Y) antisense adenoviral vector may be a useful treatment strategy in a variety of human malignant neoplasias, in which HMGI(Y) gene overexpression is a general event. (literal)

Prodotto di

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• MONICA FEDELE (Unità di personale interno)
• ALFREDO FUSCO (Persona)

Incoming links:

Autore CNR di

• ALFREDO FUSCO (Persona)
• MONICA FEDELE (Unità di personale interno)

Prodotto

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Proceedings of the National Academy of Sciences of the United States of America (Rivista)