Preliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with polycystic ovary syndrome. (Articolo in rivista)

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  • Preliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with polycystic ovary syndrome. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Savastano S; Valentino R; Pizza G; De Rosa A; Orio F; Passaretti F; Formisano P; Lombardi G; Beguinot F; Colao A (2010)
    Preliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with polycystic ovary syndrome.
    in Journal of Endocrinology; Kurtis, Milano (Italia)
    (literal)
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  • Savastano S; Valentino R; Pizza G; De Rosa A; Orio F; Passaretti F; Formisano P; Lombardi G; Beguinot F; Colao A (literal)
Pagina inizio
  • 446 (literal)
Pagina fine
  • 450 (literal)
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  • 33 (literal)
Rivista
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  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples; IEOS-CNR; Endocrinology, University Parthenope of Naples; Department of Cellular and Molecular Biology and Pathology, University Federico II of Naples, Naples, Italy (literal)
Titolo
  • Preliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with polycystic ovary syndrome. (literal)
Abstract
  • Background: The cellular abundance of the phosphoprotein enriched in diabetes (PED/PEA-15), a 15 kDa protein related to insulin resistance (IR), is increased in women with polycystic ovary syndrome (PCOS). Aim: To investigate whether metformin (MET) has additive effects on PED/PEA-15 protein levels. Material/subjects and methods: This is an open label, prospective clinical study over 6 months. Ten hyperandrogenic obese PCOS women [age: 24.6±1.6 yr; body mass index (BMI): 30.7±1.2 kg/m2] were treated with MET (1250 mg/day). Ten age- and BMI-matched normo-androgenic women were used as controls. Outcome measures are: PED/PEA-15 protein levels, fasting plasma glucose and insulin (FPI), reciprocal index of homeostasis model assessment of insulin resistance (1/HOMA-IR); quantitative insulin sensitivity check index (QUICKI); wholebody insulin sensitivity index (ISI); SHBG; total testosterone; free androgen index (FAI). Results: At baseline FPI and PED/PEA-15 protein levels were higher, while 1/HOMA-IR, QUICKI, and ISI were lower (p<0.001) in MET group than in controls. After treatment, independently of body weight and hyperandrogenism, FPI, and PED/PEA-15 protein levels decreased (p=0.001 and 0.004, respectively), while, 1/HOMA-IR, QUICKI, and ISI increased (p<0.001). PED/PEA-15 protein levels correlated significantly with ISI either before (r=0.636; p=0.048), and after treatment (r=0.758; p=0.011). Conclusions: PED/PEA-15 protein levels reduced after a short course of treatment with MET in a group hyperandrogenic obese PCOS women. This effect was independent of body weight and hyperandrogenism, and correlated with ISI, thus adding a further benefit to obese PCOS women. (literal)
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