Liver Fat Is Reduced by an Isoenergetic MUFA Diet in a Controlled Randomized Study in Type 2 Diabetic Patients (Articolo in rivista)

Type
Label
  • Liver Fat Is Reduced by an Isoenergetic MUFA Diet in a Controlled Randomized Study in Type 2 Diabetic Patients (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2337/dc12-0033 (literal)
Alternative label
  • LUTGARDA BOZZETTO, ANNA PRINSTER, GIOVANNI ANNUZZI, LUCIA COSTAGLIOLA, ANNA MANGIONE, ALESSANDRA VITELLI, RAFFAELLA MAZZARELLA, MARGARET LONGOBARDO, MARCELLO MANCINI, CARLO VIGORITO, GABRIELE RICCARDI, ANGELA A. RIVELLESE (2012)
    Liver Fat Is Reduced by an Isoenergetic MUFA Diet in a Controlled Randomized Study in Type 2 Diabetic Patients
    in Diabetes care (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • LUTGARDA BOZZETTO, ANNA PRINSTER, GIOVANNI ANNUZZI, LUCIA COSTAGLIOLA, ANNA MANGIONE, ALESSANDRA VITELLI, RAFFAELLA MAZZARELLA, MARGARET LONGOBARDO, MARCELLO MANCINI, CARLO VIGORITO, GABRIELE RICCARDI, ANGELA A. RIVELLESE (literal)
Pagina inizio
  • I429 (literal)
Pagina fine
  • I435 (literal)
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  • 35 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 7 (literal)
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  • Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy; Biostructure and Bioimaging Institute, National Research Council, Naples, Italy; Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy; Department of Biomorphological and Functional Science, Federico II University, Naples, Italy. (literal)
Titolo
  • Liver Fat Is Reduced by an Isoenergetic MUFA Diet in a Controlled Randomized Study in Type 2 Diabetic Patients (literal)
Abstract
  • OBJECTIVE: To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: With use of a factorial 2 × 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plus metformin treatment were assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high-fiber/low-glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by (1)H NMR. RESULTS: Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS: An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes. (literal)
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