Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions. (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/bip.21680 (literal)

Alternative label

• Malgieri, G; Zaccaro, L; Leone, M ; Bucci, E; Esposito, S; Baglivo, I; Del Gatto, A; Russo, L; Scandurra, R; Pedone, PV; Fattorusso, R; Isernia, C. (2011)
  Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions.
  in Biopolymers (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Malgieri, G; Zaccaro, L; Leone, M ; Bucci, E; Esposito, S; Baglivo, I; Del Gatto, A; Russo, L; Scandurra, R; Pedone, PV; Fattorusso, R; Isernia, C. (literal)

Pagina inizio

• 801 (literal)

Pagina fine

• 810 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 95 (literal)

Rivista

• Biopolymers (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Scienze Ambientali, II University of Naples, via Vivaldi 43, 81100 Caserta, Italy Istituto di Biostrutture e Bioimmagini - CNR, Via Mezzocannone 16, 80134 Napoli, Italy Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples, \"Federico II\", Via Mezzocannone 16, 80134 Napoli, Italy Dipartimento di Scienze Biochimiche \"A. Rossi Fanelli\", University of Rome \"La Sapienza\", Piazzale Aldo Moro 5, 00185 Roma, Italy (literal)

Titolo

• Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions. (literal)

Abstract

• Among heavy metals, whose toxicity cause a steadily increasing of environmental pollution, cadmium is of special concern due to its relatively high mobility in soils and potential toxicity at low concentrations. Given their ubiquitous role, zinc fingers domains have been proposed as mediators for the toxic and carcinogenic effects exerted by xenobiotic metals. To verify the structural effects of zinc replacement by cadmium in zinc fingers, we have determined the high resolution structure of the single Cys2His2 zinc finger of the Arabidopsis thaliana SUPERMAN protein (SUP37) complexed to the cadmium ion by means of UV-vis and NMR techniques. SUP37 is able to bind Cd(II), though with a dissociation constant higher than that measured for Zn(II). Cd-SUP37 retains the ??? fold but experiences a global structural rearrangement affecting both the relative orientation of the secondary structure elements and the position of side chains involved in DNA recognition: among them Ser17 side chain, which we show to be essential for DNA binding, experiences the largest displacement. © 2011 Wiley Periodicals, Inc. Biopolymers 95: 801-810, 2011. (literal)

Prodotto di

• Sviluppo di sistemi molecolari per il delivery di farmaci e diagnostici (PM.P01.003.003) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• MARILISA LEONE (Persona)
• LAURA ZACCARO (Persona)
• ANNARITA DEL GATTO (Persona)

Incoming links:

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Sviluppo di sistemi molecolari per il delivery di farmaci e diagnostici (PM.P01.003.003) (Modulo)

Autore CNR di

• LAURA ZACCARO (Persona)
• MARILISA LEONE (Persona)
• ANNARITA DEL GATTO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biopolymers (Rivista)