Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. (Articolo in rivista)

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  • Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/sj.onc.1208501 (literal)
Alternative label
  • Fedele M; Pentimalli F; Baldassarre G; Battista S; Klein-Szanto AJ; Kenyon L; Visone R; De Martino I; Ciarmiello A; Arra C; Viglietto G; Croce CM; Fusco A. (2005)
    Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.
    in Oncogene (Basingstoke)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Fedele M; Pentimalli F; Baldassarre G; Battista S; Klein-Szanto AJ; Kenyon L; Visone R; De Martino I; Ciarmiello A; Arra C; Viglietto G; Croce CM; Fusco A. (literal)
Pagina inizio
  • 3427 (literal)
Pagina fine
  • 3435 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 24 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita` di Napoli 'Federico II', 80131 Naples, Italy; Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA; Experimental Histopathology, Fox-Chase Cancer Center, Philadelphia, PA 19111, USA; Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA; Istituto dei Tumori di Napoli Fondazione 'G. Pascale', via Semmola, 80131 Naples, Italy; 6NOGEC (Naples Oncogenomic Center) - CEINGE, Biotecnologie Avanzate, Naples, Italy (literal)
Titolo
  • Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. (literal)
Abstract
  • Overexpression of HMGA1 proteins is a constant feature of human carcinomas.Moreover , rearrangements of this gene have been detected in several human benign tumors of mesenchymal origin.To define the role of these proteins in cell transformation in vivo, we have generated transgenic mice overexpressing ubiquitously the HMGA1 gene. These mice developed mixed growth hormone/prolactin cell pituitary adenomas and natural killer (NK)-T/NK cell lymphomas.The HMGA1-induced expression of IL-2 and IL-15 proteins and their receptors may account for the onset of these lymphomas.At odds with mice overexpressing a wild-type or a truncated HMGA2 protein, adrenal medullar hyperplasia and pancreatic islet cell hyperplasia frequently occurred and no increase in body size and weight was observed in HMGA1 mice.Take n together, these data indicate an oncogenic role of the HMGA1 gene also in vivo. (literal)
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