New insights on oxidative stress in cancer (Articolo in rivista)

Type
Label
  • New insights on oxidative stress in cancer (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Visconti R; Grieco D (2009)
    New insights on oxidative stress in cancer
    in Current opinion in drug discovery & development
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Visconti R; Grieco D (literal)
Pagina inizio
  • 240 (literal)
Pagina fine
  • 245 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • I.F. 2009= 4.904; numero di citazioni al 31/12/2011= 31 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • R. Visconti= Istituto per l'Endocrinologia e l'Oncologia Sperimentale \"G. Salvatore\", Consiglio Nazionale delle Ricerche, Napoli, Italy. D. Grieco= CEINGE Biotecnologie Avanzate, Napoli, Italy e Facolta' di Scienze Biotecnologiche, DBPCM, Universita' di Napoli \"Federico II\", Italy (literal)
Titolo
  • New insights on oxidative stress in cancer (literal)
Abstract
  • Cancer initiation and progression has been linked to oxidative stress, a condition in which the balance between production and disposal of reactive oxygen or nitrogen species is altered. Oxidative stress has several protumorigenic effects, such as increasing DNA mutation rate or inducing DNA damage, genome instability and cell proliferation. Conversely, oxidative stress also exerts antitumorigenic actions, and it is has been linked to senescence and apoptosis, two major mechanisms that counteract tumor development. In this review, recent findings that relate oxidative stress to cancer-associated conditions, such as chronic inflammation, steroid hormone signaling and altered chromosome segregation, are highlighted, and how these studies may identify new targets for the development of drugs and strategies for cancer prevention and cure is discussed. (literal)
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