The DREAM protein is associated with thyroid enlargement and nodular development. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The DREAM protein is associated with thyroid enlargement and nodular development. (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1210/me.2008-0466 (literal)

Alternative label

• Rivas M, Mellström B, Torres B, Cali G, Ferrara AM, Terracciano D, Zannini M, Morreale de Escobar G, Naranjo JR. (2009)
  The DREAM protein is associated with thyroid enlargement and nodular development.
  in Molecular endocrinology (Baltim. Md.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Rivas M, Mellström B, Torres B, Cali G, Ferrara AM, Terracciano D, Zannini M, Morreale de Escobar G, Naranjo JR. (literal)

Pagina inizio

• 862 (literal)

Pagina fine

• 870 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Molecular endocrinology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Departamento Biología Molecular y Celular, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas (CSIC), 28049 Madrid, Spain; CIBERNED-CNB Centro Investigacion Biomedica en Red de Enfermedades Neurodegerenativas; Instituto di Endocrinologia ed Oncologia Sperimentale-Consiglio Nazionale delle Ricerche and Dipartimento di Biologia e Patologia Cellulare e Molecolare, 80131 Napoli, Italy; Instituto de Investigaciones Biome ? dicas, CIBERER-IIB Centro Investigacion Biomedica en Red de Enfermedades Raras, CSIC, 28029 Madrid, Spain (literal)

Titolo

• The DREAM protein is associated with thyroid enlargement and nodular development. (literal)

Abstract

• G protein-coupled receptors (GPCRs) are involved in the pathophysiology of a wide range of diseases and constitute an attractive therapeutic target. In the thyroid gland, TSH receptor (TSHR), a member of the GPCR family, is a major regulator of thyroid differentiation and function. Alterations in TSHR activity are often involved in the development of pathologies such as thyroid cancer and thyroid enlargement (goiter). Here we show that DREAM (downstream regulatory element antagonist modulator) modulates TSHR activity through a direct protein-protein inter- action that promotes coupling between the receptor and G?s. In transgenic mice, DREAM over- expression provokes a marked enlargement of the thyroid gland. Increased levels of DREAM protein were observed in human multinodular goiters, suggesting a novel etiopathogenic mech- anism in nodular development in humans. Taken together, these findings identify a mechanism for the control of TSHR activity and provide a new approach for the study and treatment of thyroid pathologies associated with impaired TSHR function. (literal)

Prodotto di

• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• MARIASTELLA ZANNINI (Persona)
• GAETANO CALI' (Unità di personale interno)

Incoming links:

Autore CNR di

• GAETANO CALI' (Unità di personale interno)
• MARIASTELLA ZANNINI (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular endocrinology (Rivista)