C-reactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• C-reactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.cardiores.2005.05.010 (literal)

Alternative label

• Cirillo P, Golino P, Calabro P, Calì G, Ragni M, De Rosa S, Cimmino G, Pacileo M, De Palma R, Forte L, Gargiulo A, Granato Corigliano F, Angri V, Spagnuolo R, Nitsch L, Chiariello M. (2005)
  C-reactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation.
  in Cardiovascular research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cirillo P, Golino P, Calabro P, Calì G, Ragni M, De Rosa S, Cimmino G, Pacileo M, De Palma R, Forte L, Gargiulo A, Granato Corigliano F, Angri V, Spagnuolo R, Nitsch L, Chiariello M. (literal)

Pagina inizio

• 47 (literal)

Pagina fine

• 55 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://cardiovascres.oxfordjournals.org/content/68/1/47 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 68 (literal)

Rivista

• Cardiovascular research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Naples 2, Div Cardiol, Naples, Italy Univ Naples Federico II, Div Cardiol, Naples, Italy IEOS G Salvatore, Natl Res Council, Naples, Italy Univ Naples 2, Dept Clin & Expt Med, Naples, Italy Univ Naples Federico II, Dept Mol & Cellular Biol & Pathol, Naples, Italy (literal)

Titolo

• C-reactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation. (literal)

Abstract

• OBJECTIVE: Inflammation plays a pivotal role in atherothrombosis. In addition to being a prognostic marker for major cardiovascular events, recent data indicate that C-reactive protein (CRP) might directly promote atherothrombosis by exerting direct effects on vascular cells. The aim of the present study was to determine whether CRP might affect the prothrombotic and proliferative characteristics of endothelial (ECs) and smooth muscle cells (SMCs). METHODS AND RESULTS: Incubation of ECs and SMCs with CRP resulted in a dose-dependent activation of cell proliferation, which was mediated by activation of the p44/42 MAP Kinase (ERK 1/2) pathway. In addition, CRP also induced tissue factor (TF) expression in both cell types in a dose-dependent fashion, exerting its effect at the transcriptional level, as demonstrated by semiquantitative and by real time PCR. Activation of the transcription factor, NF-kappaB, by CRP was demonstrated by EMSA and by suppression of TF expression by the NF-kappaB inhibitor, pyrrolidine-dithio-carbamate ammonium. CONCLUSIONS: These data indicate that CRP exerts direct effects on ECs and SMCs by promoting proliferation and TF expression and support the notion that CRP, besides representing a marker of inflammation, is an effector molecule able to induce a pro-atherothrombotic phenotype in cells of the vessel wall. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)

Autore CNR

• GAETANO CALI' (Unità di personale interno)
• LUCIO NITSCH (Persona)

Incoming links:

Autore CNR di

• GAETANO CALI' (Unità di personale interno)
• LUCIO NITSCH (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cardiovascular research (Rivista)