http://www.cnr.it/ontology/cnr/individuo/prodotto/ID211457

Insights into the polymorphism of glycine: membrane crystallization in an electric field (Articolo in rivista)

Type

Label

Insights into the polymorphism of glycine: membrane crystallization in an electric field (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Gianluca Di Profio, Mika T. Reijonen, Rocco Caliandro, Antonietta Guagliardi, Efrem Curcio, and Enrico Drioli (2013)
Insights into the polymorphism of glycine: membrane crystallization in an electric field
in PCCP. Physical chemistry chemical physics (Print)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Gianluca Di Profio, Mika T. Reijonen, Rocco Caliandro, Antonietta Guagliardi, Efrem Curcio, and Enrico Drioli (literal)

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Institute on Membrane Technology (ITM-CNR), Rende, Italy Pharmika Systems Ltd, Helsinki, Finland Institute of Crystallography (IC-CNR), Bari, Italy Department of Chemical Engineering and Materials, University of Calabria, Rende, Italy (literal)

Titolo

Insights into the polymorphism of glycine: membrane crystallization in an electric field (literal)

Abstract

In this work we studied glycine crystallization with two main objectives: (i) to get improved control of crystal growth and polymorphic selectivity of organic molecules; (ii) to achieve additional insights into the nucleation mechanisms of glycine polymorphs. To reach these goals, membrane crystallization technology, a tool which allows improved control of supersaturation in solution crystallization, was used under different operating conditions: the variable solvent removal rate, acidic and almost neutral pH, the presence of a pulsed electric field. The traditional explanation for the crystallization of a and g glycine polymorphs from aqueous solution is based on the general cyclic dimer hypothesis and the self-poisoning mechanism. In contrast with both the conventional theories, experimental results suggest that the relative nucleation rates with respect to the relative growth kinetics of the two forms under the different conditions play a dominant role in determining the polymorphic outcome. Our results instead support a molecular nucleation route where open chain dimers can behave as building units for both g- and a-glycines in the rate determining structuring step of the two-step nucleation mechanism. (literal)

Prodotto di