http://www.cnr.it/ontology/cnr/individuo/prodotto/ID210728
Ibuprofen plus Isosorbide Dinitrate treatment in the mdx mice ameliorates dystrophic heart structure (Articolo in rivista)
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- Label
- Ibuprofen plus Isosorbide Dinitrate treatment in the mdx mice ameliorates dystrophic heart structure (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.phrs.2013.04.009 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Clara Scioratia; Lidia Staszewsky; Vanessa Zambelli; Ilaria Russo; Monica Salio; Deborah Novelli; Giuseppe Di Grigoli; Rosa Maria Moresco; Emilio Clementi; Roberto Latinib. (literal)
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- Division of Regenerative Medicine, Ospedale San Raffaele Scientific Institute, Milan, Italy. Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. Department of Health Science, University of Milano-Bicocca, Monza, Italy. Nuclear Medicine Department and PET Centre, San Raffaele Scientific Institute, Milan, Italy. IBFM-CNR, Segrate (MI), Italy. Fondazione TECNOMED, Department of Health Sciences, University of Milan-Bicocca, Monza, Italy. Unit of Clinical Pharmacology, CNR Institute of Neuroscience, Department of Biomedical and Clinical Sciences, University Hospital \"Luigi Sacco\", Università di Milano, Milan, Italy. Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy. (literal)
- Titolo
- Ibuprofen plus Isosorbide Dinitrate treatment in the mdx mice ameliorates dystrophic heart structure (literal)
- Abstract
- Background: Co-administration of ibuprofen (IBU) and isosorbide dinitrate (ISDN) provides synergistic beneficial effects on dystrophic skeletal muscle. Whether this treatment has also cardioprotective effects in this disease was still unknown. Aims: To evaluate the effects of co-administration of IBU and ISDN (a) on left ventricular (LV) structure and function, and (b) on cardiac inflammatory response and fibrosis in mdx mice. Methods: Three groups of mice were studied: mdx mice treated with IBU (50 mg kg-1) + ISDN (30 mg kg-1) administered daily in the diet, mdx mice that received standard diet without drugs and wild type aged-matched mice. Animals were analysed after 10-11 months of treatment. Structural and functional parameters were evaluated by echocardiography while histological analyses were performed to evaluate inflammatory response, collagen deposition, cardiomyocyte number and area. Results: Treatment for 10-11 months with IBU + ISDN preserved LV wall thickness and LV mass. Drug treatment also preserved the total number of cardiomyocytes in the LV and attenuated the increase in cardiomyocyte size, when compared to untreated mdx mice. Moreover, a trend towards a decreased number of inflammatory cells, a reduced LV myocardial interstitial fibrosis and an enhanced global LV function response to stress was observed in treated mdx mice. Conclusions: Treatment for 10-11 months with IBU + ISDN is effective in preventing the alterations in LV morphology of mdx mice while not reaching statistical significance on LV function and cardiac inflammation. (literal)
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