Investigation of bacterial resistance to the immune system response: Cepacian depolymerisation by reactive oxygen species (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Investigation of bacterial resistance to the immune system response: Cepacian depolymerisation by reactive oxygen species (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1177/1753425911435954 (literal)

Alternative label

• B.Cuzzi, P.Cescutti, L.Furlanis, C.Lagatolla, L.Sturiale, D.Garozzo, R.Rizzo (2012)
  Investigation of bacterial resistance to the immune system response: Cepacian depolymerisation by reactive oxygen species
  in Innate immunity (Print); Sage Publications Ltd., London (Regno Unito)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• B.Cuzzi, P.Cescutti, L.Furlanis, C.Lagatolla, L.Sturiale, D.Garozzo, R.Rizzo (literal)

Pagina inizio

• 661 (literal)

Pagina fine

• 671 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://ini.sagepub.com/content/18/4/661.abstract (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 18 (literal)

Rivista

• Innate immunity (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Scienze della Vita, Università di Trieste, Trieste, Italy Istituto di Chimica e Tecnologia dei Polimeri, Catania, Italy (literal)

Titolo

• Investigation of bacterial resistance to the immune system response: Cepacian depolymerisation by reactive oxygen species (literal)

Abstract

• Reactive oxygen species (ROS) are part of the weapons used by the immune system to kill and degrade infecting microorganisms. Bacteria can produce macromolecules, such as polysaccharides, that are able to scavenge ROS. Species belonging to the Burkholderia cepacia complex are involved in serious lung infection in cystic fibrosis patients and produce a characteristic polysaccharide, cepacian. The interaction between ROS and bacterial polysaccharides was first investigated by killing experiments, where bacteria cells were incubated with sodium hypochlorite (NaClO) with and without prior incubation with cepacian. The results showed that the polysaccharide had a protective effect towards bacterial cells. Cepacian was then treated with different concentrations of NaClO and the course of reactions was followed by means of capillary viscometry. The degradation products were characterised by size-exclusion chromatography, NMR and mass spectrometry. The results showed that hypochlorite depolymerised cepacian, removed side chains and O-acetyl groups, but did not cleave the glycosidic bond between glucuronic acid and rhamnose. The structure of some oligomers produced by NaClO oxidation is reported. (literal)

Editore

• Sage Publications Ltd. (Editore)

Prodotto di

• Istituto di chimica e tecnologia dei polimeri (ICTP) (Istituto)
• Glicomica e Proteomica per la ricerca di biomarcatori per la diagnosi e la terapia di patologie congenite, tumorali e infiammatorie. (PM.P06.013.001) (Modulo)

Autore CNR

• DOMENICO GAROZZO (Unità di personale interno)
• LUISELLA STURIALE (Persona)

Insieme di parole chiave

• Keywords of "Investigation of bacterial resistance to the immune system response: Cepacian depolymerisation by reactive oxygen species" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DOMENICO GAROZZO (Unità di personale interno)
• LUISELLA STURIALE (Persona)

Prodotto

• Istituto di chimica e tecnologia dei polimeri (ICTP) (Istituto)
• Glicomica e Proteomica per la ricerca di biomarcatori per la diagnosi e la terapia di patologie congenite, tumorali e infiammatorie. (PM.P06.013.001) (Modulo)

Editore di

• Sage Publications Ltd. (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Innate immunity (Rivista)

Insieme di parole chiave di

• Keywords of "Investigation of bacterial resistance to the immune system response: Cepacian depolymerisation by reactive oxygen species" (Insieme di parole chiave)