Intracellular route and mechanism of action of ERB-hRNase, a human anti-ErbB2 anticancer immunoagent. (Articolo in rivista)

Type
Label
  • Intracellular route and mechanism of action of ERB-hRNase, a human anti-ErbB2 anticancer immunoagent. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • De Lorenzo C, Di Malta C, Cali G, Troise F, Nitsch L, D'Alessio G. (2007)
    Intracellular route and mechanism of action of ERB-hRNase, a human anti-ErbB2 anticancer immunoagent.
    in FEBS letters (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Lorenzo C, Di Malta C, Cali G, Troise F, Nitsch L, D'Alessio G. (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Intracellular route and mechanism of action of ERB-hRNase, a human anti-ErbB2 anticancer immunoagent. (literal)
Abstract
  • Human anti-ErbB2 immunoRNase with Erbicin fused to HP-RNase (ERB-hRNase) is a fully human immunoRNase made up of human pancreatic RNase fused to a human anti-ErbB2 scFv. It binds selectively with high affinity to ErbB2-positive cells, and specifically inhibits their proliferation, in vitro and in vivo. An investigation of its mechanism of action and its intracellular destination has revealed that ERB-hRNase depends on its RNase activity for cytotoxic action; it reaches the cytosol directly from the endosomal compartment; it is inhibited by the cytosolic RNase inhibitor (cRI), but the levels that ERB-hRNase reaches in the cytosol neutralize cRI, thus inducing cell death by apoptosis. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it