Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1210/en.2006-1344 (literal)

Alternative label

• Cali G, Zannini M, Rubini P, Tacchetti C, D'Andrea B, Affuso A, Wintermantel T, Boussadia O, Terracciano D, Silberschmidt D, Amendola E, De Felice M, Schutz G, Kemler R, Di Lauro R, Nitsch L. (2007)
  Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation
  in Endocrinology (Philadelphia)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cali G, Zannini M, Rubini P, Tacchetti C, D'Andrea B, Affuso A, Wintermantel T, Boussadia O, Terracciano D, Silberschmidt D, Amendola E, De Felice M, Schutz G, Kemler R, Di Lauro R, Nitsch L. (literal)

Pagina inizio

• 2737 (literal)

Pagina fine

• 2746 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 148 (literal)

Rivista

• Endocrinology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Naples Federico II, Dipartimento Biol & Patol Cellulare & Mol, I-80131 Naples, Italy; Univ Genoa, Dept Expt Med, IFOM Ctr Cell Oncol & Ultrastruct, I-16145 Genoa, Italy; Univ Genoa, MicroSCoBiO Res Ctr, I-16145 Genoa, Italy; CNR, Ist Endocrinol & Oncol Sperimentale, I-80131 Naples, Italy; BIOGEM Biotechnol & Mol Genet So Italy, I-83031 Avellino, Italy; Deutsch Krebsforschungszentrum, Dept Mol Biol Cell 1, D-69120 Heidelberg, Germany; Max Planck Inst, D-80804 Freiburg, Germany; Staz Zool A Dohrn, I-80121 Naples, Italy (literal)

Titolo

• Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation (literal)

Abstract

• We have conditionally inactivated the E-cadherin gene in the thyroid follicular cells of mouse embryo to unravel its role in thyroid development. We used the Cre-loxP system in which the Cre-recombinase was expressed under the control of the tissue-specific thyroglobulin promoter that becomes active at embryonic d 15. At postnatal d 7, thyroid follicle lumens in the knockout mice were about 30% smaller with respect to control mice and had an irregular shape. E-cadherin was almost completely absent in thyrocytes, beta-catenin was significantly reduced, whereas no change in gamma-catenin was detected. alpha-Catenin was also reduced on the cell plasma membrane. Despite the dramatic loss of E-cadherin and beta-catenin, cell-cell junctions were not affected, the distribution of tight junction proteins was unaltered, and no increase of thyroglobulin circulating in the blood was observed. In addition, we found that other members of the cadherin family, the R-cadherin and the Ksp-cadherin, were expressed in thyrocytes and that their membrane distribution was not altered in the E-cadherin conditional knockout mouse. Our results indicate that E-cadherin has a role in the development of the thyroid gland and in the expression of beta-catenin, but it is not essential for the maintenance of follicular cell adhesion. (literal)

Prodotto di

• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• MARIASTELLA ZANNINI (Persona)
• GAETANO CALI' (Unità di personale interno)

Incoming links:

Autore CNR di

• GAETANO CALI' (Unità di personale interno)
• MARIASTELLA ZANNINI (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Endocrinology (Rivista)