http://www.cnr.it/ontology/cnr/individuo/prodotto/ID21034
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas. (Articolo in rivista)
- Type
- Label
- UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/sj.onc.1210010 (literal)
- Alternative label
MT Berlingieri1, P Pallante1, M Guida2, C Nappi2, V Masciullo3, G Scambia3, A Ferraro4,
V Leone4, A Sboner5, M Barbareschi6, A Ferro6, G Troncone7 and A Fusco1,4 (2007)
UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas.
in Oncogene (Basingstoke)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- MT Berlingieri1, P Pallante1, M Guida2, C Nappi2, V Masciullo3, G Scambia3, A Ferraro4,
V Leone4, A Sboner5, M Barbareschi6, A Ferro6, G Troncone7 and A Fusco1,4 (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- https://www.nature.com/onc (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta` di Medicina e Chirurgia di Napoli, Universita` degli Studi di Napoli 'Federico II', Naples, Italy;
2Dipartimento di Ginecologia e Ostetricia, e Fisiopatologia della Riproduzione Umana, Facolta` di Medicina e Chirurgia di Napoli, Universita` degli Studi di Napoli 'Federico II', Naples, Italy;
3Istituto di Clinica Ostetrica e Ginecologica, Universita` Cattolica del S.Cuore, Rome, Italy;
4NOGEC (Naples Oncogenomic Center)-CEINGE, Biotecnologie Avanzate-Napoli, & SEMM - European School of Molecular Medicine - Naples Site, Naples, Italy;
5Bioinformatics - SRA Division ITC-irst, Centre for Scientific and Technological Research, Povo (Trento), Italy;
6U.O. Anatomia Patologica Ospedale S. Chiara Largo Medaglie d'Oro Trento, Italy
7Dipartimento di Anatomia Patologica e Citopatologia, Facolta` di Medicina e Chirurgia, Universita` di Napoli 'Federico II', Naples, Italy (literal)
- Titolo
- UbcH10 expression may be a useful tool in the prognosis of ovarian carcinomas. (literal)
- Abstract
- The UbcH10 gene codes for a protein that belongs to the
ubiquitin-conjugating enzyme family. Previous studies of
our group suggest UbcH10 expression as a valid indicator
of the proliferative and aggressive status of thyroid
carcinomas. Therefore, to better understand the process
of ovarian carcinogenesis, and to look for possible tools to
be used as prognostic markers in these neoplasias, we
decided to extend the analysis of the UbcH10 expression
to the ovarian neoplastic disease. We found that the
UbcH10 gene was upregulated in some ovarian carcinoma
cell lines analysed. Then, immunohistochemical studies
demonstrate that UbcH10 expression significantly correlates
with the tumor grade and the undifferentiated
histotype of the ovarian carcinomas. Furthermore, a
significant relationship between UbcH10 expression and
overall survival was observed. Finally, the block of
UbcH10 protein synthesis by RNA interference inhibited
the growth of ovarian carcinoma cell lines, suggesting a
role of UbcH10 overexpression in ovarian carcinogenesis.
Therefore, all these data taken together suggest the
possibility to use UbcH10 detection as a marker for the
diagnosis and prognosis of these neoplastic diseases and
open the perspective of a therapy of some ovarian
carcinomas based on the suppression of the UbcH10
synthesis and/or function. (literal)
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