Recombinant Human Erythropoietin Increases Frataxin Protein Expression Without Increasing mRNA Expression. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Recombinant Human Erythropoietin Increases Frataxin Protein Expression Without Increasing mRNA Expression. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s12311-008-0036-x (literal)

Alternative label

• Acquaviva F, Castaldo I, Filla A, Giacchetti M, Marmolino D, MONTICELLI A, Pinelli M, Saccà F, Cocozza S. (2008)
  Recombinant Human Erythropoietin Increases Frataxin Protein Expression Without Increasing mRNA Expression.
  in Cerebellum (Lond., Print); Springer New York, New York (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Acquaviva F, Castaldo I, Filla A, Giacchetti M, Marmolino D, MONTICELLI A, Pinelli M, Saccà F, Cocozza S. (literal)

Pagina inizio

• 360 (literal)

Pagina fine

• 365 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• Cerebellum (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• Scopus (literal)
• Google Scholar (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Medical Genetics Unit, Department of Cellular and Molecular Biology, University of Naples Federico II, Via Pansini 5, Naples 80131, Italy Department of Neurological Sciences, University of Naples Federico II, Via Pansini 5, Naples 80131, Italy (literal)

Titolo

• Recombinant Human Erythropoietin Increases Frataxin Protein Expression Without Increasing mRNA Expression. (literal)

Abstract

• Friedreich's ataxia is an autosomal recessive neurodegenerative disease that is due to the loss of function of the frataxin protein. The molecular basis of this disease is still a matter of debate and treatments have so far focused on managing symptoms. Drugs that can increase the amount of frataxin protein offer a possible therapy for the disease. One such drug is recombinant human erythropoietin (rhu-EPO). Here, we report the effects of rhu-EPO on frataxin mRNA and protein in primary fibroblast cell cultures derived from Friedreich's ataxia patients. We observed a slight but significant increase in the amount of frataxin protein. Interestingly, we did not observe any increase in the messenger RNA expression at any of the times and doses tested, suggesting that the regulatory effects of rhu-EPO on the frataxin protein was at the post-translational level. These findings could help the evaluation of the treatment with erythropoietin as a potential therapeutic agent for Friedreich's ataxia. (literal)

Editore

• Springer New York (Editore)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002) (Modulo)

Autore CNR

• ANTONELLA MONTICELLI (Persona)

Incoming links:

Autore CNR di

• ANTONELLA MONTICELLI (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002) (Modulo)

Editore di

• Springer New York (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cerebellum (Rivista)