http://www.cnr.it/ontology/cnr/individuo/prodotto/ID21000
The expression of the high mobility group HMGI(Y) proteins correlates with the malignant phenotype of human thyroid neoplasias (Articolo in rivista)
- Type
- Label
- The expression of the high mobility group HMGI(Y) proteins correlates with the malignant phenotype of human thyroid neoplasias (Articolo in rivista) (literal)
- Anno
- 1995-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Chiappetta G; Bandiera A; Berlingieri MT; Visconti R; Manfioletti G; Battista S; Martinez-Tello FJ; Santoro M; Giancotti V; Fusco A (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- G. Chiappetta; S. Battista= Istituto Nazionale dei Tumori di Napoli, fondazione senatore Pascale, Napoli, Italy
A. Bandiera; G. Manfioletti; V. Giancotti= Dipartimento di Biochimica, Biofisica e Chimica delle macromolecole, Universita' degli Studi di Trieste, Italy
M. T. Berlingieri; M. Santoro= Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Centro di endocrinologiaed Oncologia Sperimentale del CNR, Universita' degli Studi di Napoli, Italy
F. J. Martinez-Tello= Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Spain
A. Fusco= Dipartimento di Medicina Sperimentale e Clinica, Universita' degli Studi di Reggio Calabria, Catanzaro, Italy (literal)
- Titolo
- The expression of the high mobility group HMGI(Y) proteins correlates with the malignant phenotype of human thyroid neoplasias (literal)
- Abstract
- High Mobility Group I (HMGI) proteins are nuclear proteins involved in the regulation of chromatin structure and function. Elevated expression of the HMGI proteins (HMGI, HMGY and HMGI-C) has been correlated with the presence of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells, and in several experimental carcinomas. Here, we demonstrate that HMGI and HMGY proteins are expressed in human thyroid carcinomas and thyroid carcinoma cell lines, but not in adenomas, goiters, normal thyroid tissues and cells. These results indicate a correlation between HMGI and HMGY expression and the malignant phenotype of thyroid neoplasias, suggesting that these proteins may be used as markers in thyroid cancer. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi