An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionary conserved enhancer. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionary conserved enhancer. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1128/MCB.26.8.3308-3318.2006 (literal)

Alternative label

• D. Antonini, B. Rossi, R. Han, A. Minichiello, T. Di Palma, M. Corrado, S. Banfi, M. Zannini, J. L. Brissette, C. Missero. (2006)
  An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionary conserved enhancer.
  in Molecular biology of the cell
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D. Antonini, B. Rossi, R. Han, A. Minichiello, T. Di Palma, M. Corrado, S. Banfi, M. Zannini, J. L. Brissette, C. Missero. (literal)

Pagina inizio

• 3308 (literal)

Pagina fine

• 3318 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 26 (literal)

Rivista

• Molecular biology of the cell (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Telethon Institute of Genetics and Medicine, 80131 Napoli, Italy; Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 021292; Istituto di Endocrinologia ed Oncologia Sperimentale-CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, 80131 Napoli, Italy (literal)

Titolo

• An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionary conserved enhancer. (literal)

Abstract

• p63, a p53 family member, is essential for the development of various stratified epithelia and is one of the earliest markers of many ectodermal structures, including the epidermis, oral mucosa, apical ectodermal ridge, and mammary gland. Genetic regulatory mechanisms controlling p63 spatial expression during development have not yet been defined. Using a genomic approach, we identified an evolutionarily conserved cis-regulatory element, located 160 kb downstream of the first p63 exon, which functions as a keratinocyte-specific enhancer and is sufficient to recapitulate expression of the endogenous gene during mouse embryogenesis. Dissection of the p63 enhancer activity revealed a positive autoregulatory loop in which the p63 proteins directly bind to and are essential regulators of the enhancer. Accordingly, transactivating p63 isoforms induce endogenous p63 expression in cells that do not normally express this gene, whereas dominant negative isoforms suppress p63 expression in keratinocytes. In addition the transcription factor AP-2 also binds to the enhancer and cooper- ates with p63 to induce its activity. These results demonstrate that a long-range autoregulatory loop is involved in the regulation of p63 expression during embryonic development and in adult cells. (literal)

Prodotto di

• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• MARIASTELLA ZANNINI (Persona)
• TINA DI PALMA (Persona)

Incoming links:

Autore CNR di

• MARIASTELLA ZANNINI (Persona)
• TINA DI PALMA (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular biology of the cell (Rivista)