The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00125-006-0455-5 (literal)

Alternative label

• Valentino R; Lupoli GA; Raciti GA; Oriente F; Farinaro E; Della Valle E; Salomone M; Riccardi G; Vaccaro O; Donnarumma G; Sesti G; Hribal ML; Cardellini M; Miele; Formisano P; Beguinot F (2006)
  The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.
  in Diabetologia (Berl.); SPRINGER, 233 SPRING ST, NEW YORK, NY 10013 (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Valentino R; Lupoli GA; Raciti GA; Oriente F; Farinaro E; Della Valle E; Salomone M; Riccardi G; Vaccaro O; Donnarumma G; Sesti G; Hribal ML; Cardellini M; Miele; Formisano P; Beguinot F (literal)

Pagina inizio

• 3058 (literal)

Pagina fine

• 3066 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 49 (literal)

Rivista

• Diabetologia (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 12 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Cellular and Molecular Biology and Pathology 'L. Califano' and C.N.R. Institute of Experimental Endocrinology and Oncology 'G. Salvatore', University of Naples 'Federico II', Naples, Italy Occupational Medicine Section, Department of Preventive Medical Sciences, Naples, Italy Department of Experimental and Clinical Medicine, University of Naples 'Federico II', Naples, Italy Department of Experimental and Clinical Medicine, University of Catanzaro 'Magna Graecia', Catanzaro, Italy (literal)

Titolo

• The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes. (literal)

Abstract

• Aims/hypothesis Overexpression of the gene encoding phosphoprotein enriched in astrocytes 15 (PEA15), also known as phosphoprotein enriched in diabetes (PED), causes insulin resistance and diabetes in transgenic mice and has been observed in type 2 diabetic individuals. The aim of this study was to investigate whether PEA15 overexpression occurs in individuals at high risk of diabetes and whether it is associated with specific type 2 diabetes subphenotypes. Subjects and methods We analysed PEA15 expression in euglycaemic first-degree relatives (FDR) of type 2 diabetic subjects. Results The expression of PEA15 in peripheral blood leucocytes (PBLs) paralleled that in fat and skeletal muscle tissues. In PBLs from the FDR, PEA15 expression was two-fold higher than in euglycaemic individuals with no family history of diabetes (control subjects), both at the protein and the mRNA level (p<0.001). The expression of PEA15 was comparable in FDR and type 2 diabetic subjects and in each group close to one-third of the subjects expressed PEA15 levels more than 2 SD higher than the mean of control subjects. Subjects with IFG with at least one type 2 diabetes-affected FDR also overexpressed PEA15 (p<0.05). In all the groups analysed, PEA15 expression was independent of sex and unrelated to age, BMI, waist circumference, systolic and diastolic BP, and fasting cholesterol, triacylglycerol and glucose levels. However, in euglycaemic FDR of type 2 diabetic subjects, PEA15 expression was inversely correlated with insulin sensitivity (r=-557, p=0.01). Conclusions/interpretation We conclude that PEA15 overexpression represents a common defect in FDR of patients with type 2 diabetes and is correlated with reduced insulin sensitivity in these individuals. (literal)

Editore

• SPRINGER, 233 SPRING ST (Editore)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002) (Modulo)

Autore CNR

• CLAUDIA MIELE (Persona)
• FRANCESCO BEGUINOT (Unità di personale esterno)
• GREGORY ALEXANDER RACITI (Unità di personale interno)
• ROSSELLA VALENTINO (Persona)

Insieme di parole chiave

• Keywords of "The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ROSSELLA VALENTINO (Persona)
• FRANCESCO BEGUINOT (Unità di personale esterno)
• CLAUDIA MIELE (Persona)
• GREGORY ALEXANDER RACITI (Unità di personale interno)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Studio dell'espressione e della funzione di geni e proteine coinvolte nel diabete di tipo 2 (SV.P16.001.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetologia (Rivista)

Editore di

• SPRINGER, 233 SPRING ST (Editore)

Insieme di parole chiave di

• Keywords of "The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes." (Insieme di parole chiave)