http://www.cnr.it/ontology/cnr/individuo/prodotto/ID209728

Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1002/jbmr.1677 (literal)

Alternative label

M. Fusaro (1); M. Noale (1); V. Viola (2); F. Galli (2); G. Tripepi (3); N. Vajente (4); M. Plebani (4); M. Zaninotto (4); G. Guglielmi (5); D. Miotto (6); L. Dalle Carbonare (7); A. D'Angelo (8); A. Naso (9); C. Grimaldi (10); D. Miozzo (8); S. Giannini (11); M. Gallieni (12); for the VItamin K Italian (VIKI) Dialysis Study Investigators (2012)
Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study.
in Journal of bone and mineral research; WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

M. Fusaro (1); M. Noale (1); V. Viola (2); F. Galli (2); G. Tripepi (3); N. Vajente (4); M. Plebani (4); M. Zaninotto (4); G. Guglielmi (5); D. Miotto (6); L. Dalle Carbonare (7); A. D'Angelo (8); A. Naso (9); C. Grimaldi (10); D. Miozzo (8); S. Giannini (11); M. Gallieni (12); for the VItamin K Italian (VIKI) Dialysis Study Investigators (literal)

Pagina inizio

2271 (literal)

Pagina fine

2278 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

27 (literal)

Rivista

Journal of bone and mineral research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

11 (literal)

Note

ISI Web of Science (WOS) (literal)
PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

[ 1 ] Consiglio Nazl Ric CNR, Inst Neurosci, Aging Sect, Padua, Italy [ 2 ] Univ Perugia, Sch Pharm, Dept Internal Med, Lab Biochem & Nutr, I-06100 Perugia, Italy [ 3 ] CNR Ist Biometeorol, Reggio Di Calabria, Italy [ 4 ] Univ Hosp Padova, Dipartimento Med Lab, Padua, Italy [ 5 ] Univ Foggia, Dept Radiol, Foggia, Italy [ 6 ] Univ Padua, Sez Radiol, Dipartimento Sci Med & Diagnost Terapie Speciali, Padua, Italy [ 7 ] Univ Verona, Dept Biomed & Surg Sci, I-37100 Verona, Italy [ 8 ] Univ Padua, Nephrol Unit, Padua, Italy [ 9 ] Hosp Padua, Nephrol & Dialysis Unit, Padua, Italy [ 10 ] Hosp San Giovanni Dio Florence, Nephrol & Dialysis Unit, Florence, Italy [ 11 ] Univ Padua, Dept Clin & Expt Med, Med Clin 4, Padua, Italy [ 12 ] Hosp San Carlo Borromeo, Nephrol & Dialysis Unit, Milan, Italy (literal)

Titolo

Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. (literal)

Abstract

Vitamin K (vitamin K1 or phylloquinone and vitamin K2, a series of menaquinones [MKs]) is involved in the production of bone and matrix amino acid gamma-carboxy-glutamic acid (Gla) proteins, regulating bone and vascular calcification. Low vitamin K concentrations are associated with increased risks of fractures and vascular calcification, and frequent complications in hemodialysis patients. We carried out an observational study to establish the prevalence of vitamin K deficiency and to assess the relationship between vitamin K status, vertebral fractures, vascular calcification, and survival in 387 patients on hemodialysis for >= 1 year. We determined plasma levels of vitamin K compound, bone-Gla-protein, matrix-Gla-protein, and routine biochemistry. Vertebral fractures (reduction in vertebral body height by >= 20%) and aortic and iliac calcifications were also investigated in a spine (D-5-L-4) radiograph. Three-year patient survival was analyzed. Important proportions of patients had deficiency of MK7 (35.4%), vitamin K1 (23.5%), and MK4 (14.5%). A total of 55.3% of patients had vertebral fractures, 80.6% had abdominal aorta calcification, and 56.1% had iliac calcification. Vitamin K1 deficiency was the strongest predictor of vertebral fractures (odds ratio [OR], 2.94; 95% confidence interval [CI], 1.38-6.26). MK4 deficiency was a predictor of aortic calcification (OR, 2.82; 95% CI, 1.14-7.01), whereas MK5 deficiency actually protected against it (OR, 0.38; 95% CI, 0.15-0.95). MK7 deficiency was a predictor of iliac calcification (OR, 1.64; 95% CI, 1.03-2.60). The presence of vertebral fractures was also a predictor of vascular calcifications (OR, 1.76; 95% CI, 1.00-3.08). Increased alkaline phosphatase and C reactive protein (CRP), age, and cerebrovascular events were predictors of mortality. Our study suggests that the vitamin K system may be important for preserving bone mass and avoiding vascular calcification in hemodialysis patients, pointing out a possible role of vitamin K in bone and vascular health. Based on our results, we suggest that the general population should also be studied for vitamin K deficiency as a possible cause of both vertebral fractures and vascular calcification. (C) 2012 American Society for Bone and Mineral Research. (literal)

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