HEPATIC STEATOSIS AND THYROID FUNCTION TESTS IN OVERWEIGHT AND OBESE CHILDREN (Articolo in rivista)

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  • HEPATIC STEATOSIS AND THYROID FUNCTION TESTS IN OVERWEIGHT AND OBESE CHILDREN (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1155/2013/381014 (literal)
Alternative label
  • 1.Pacifico Lucia;2.Bonci Enea;1.Ferraro Flavia;1.Andreoli Gianmarco;1.Bascetta Stefano;3.Chiesa Claudio (2013)
    HEPATIC STEATOSIS AND THYROID FUNCTION TESTS IN OVERWEIGHT AND OBESE CHILDREN
    in International Journal of Endocrinology (Print); Hindawi Publishing Corporation, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • 1.Pacifico Lucia;2.Bonci Enea;1.Ferraro Flavia;1.Andreoli Gianmarco;1.Bascetta Stefano;3.Chiesa Claudio (literal)
Pagina inizio
  • 1 (literal)
Pagina fine
  • 8 (literal)
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  • 2013 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1.Department of Pediatrics,Sapienza University of Rome; 2.Department of Experimental Medicine,Sapienza University of Rome; 3.Institute of Translational Pharmacology,Sapienza University of Rome (literal)
Titolo
  • HEPATIC STEATOSIS AND THYROID FUNCTION TESTS IN OVERWEIGHT AND OBESE CHILDREN (literal)
Abstract
  • Objectives. Associations between thyroid function and nonalcoholic fatty liver disease (NAFLD) are unknown in childhood. Thus, the aim of the present study was to investigate in 402 consecutive overweight/obese children the association between thyroid function tests and hepatic steatosis as well as metabolic variables. Methods. Hepatic steatosis was diagnosed by ultrasound after exclusion of infectious and metabolic disorders. Fasting serum samples were taken for determination of thyroid function (TSH, FT4, and FT3), along with alanine aminotransferase (ALT), lipid profile, glucose, insulin, and insulin resistance (IR). Results. Eighty-eight children (21.9%) had TSH above the normal range (>4.0 mIU/L). FT3 and FT4 were within the reference intervals in all subjects. Elevated TSH was associated with increased odds of having hepatic steatosis (OR 2.10 (95% CI, 1.22-3.60)), hepatic steatosis with elevated ALT (2.42 (95% CI, 1.29-4.51)), hypertriglyceridemia, elevated total cholesterol, and IR as well as metabolic syndrome (considered as a single clinical entity), after adjustment for age, gender, pubertal status, and body mass index-SD score (or waist circumference). Conclusions. In overweight/obese children, elevated TSH concentration is a significant predictor of hepatic steatosis and lipid and glucose dysmetabolism, independently of the degree of total and visceral obesity. (literal)
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