Upper limit of normal for alanine aminotransferase: Quo vadis? (Articolo in rivista)

Type
Label
  • Upper limit of normal for alanine aminotransferase: Quo vadis? (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.cca.2013.03.030 (literal)
Alternative label
  • 1.Pacifico Lucia;1.Ferraro Flavia;2.Bonci Enea;1.Anania Caterina;1.Romaggioli Sara;3.Chiesa Claudio (2013)
    Upper limit of normal for alanine aminotransferase: Quo vadis?
    in Clinica chimica acta (Print); Elsevier, Amsterdam (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • 1.Pacifico Lucia;1.Ferraro Flavia;2.Bonci Enea;1.Anania Caterina;1.Romaggioli Sara;3.Chiesa Claudio (literal)
Pagina inizio
  • 29 (literal)
Pagina fine
  • 39 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 422 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 11 (literal)
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1.Department of Pediatrics,Sapienza University of Rome 2.Department of Experimental Medicine,Sapienza University of Rome 3.Institute of Translational Pharmacology,National Research Council (literal)
Titolo
  • Upper limit of normal for alanine aminotransferase: Quo vadis? (literal)
Abstract
  • Several studies suggest that a substantial number of patients with normal serum alanine aminotransferase (ALT) levels, defined by current thresholds, have ongoing hepatic necro-inflammation and fibrosis, and are at risk of liver disease progression. A major problem lies in the definition of normality. The current upper limit of normal (ULN) for ALT was established in the 1980s when reference populations were likely to include many persons with hepatitis C virus infection and nonalcoholic fatty liver disease. Because ALT may be influenced, not only by liver disease, but also by other medical conditions, changing lifestyle factors and demographic determinants, the current ALT ULN threshold has recently been challenged. This review not only highlights current evidence on why and how ALT ULN should be redefined, but also discusses the current concerns about updating the ULN threshold for ALT. (literal)
Editore
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Editore di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it