Sustained in vitro release and cell uptake of doxorubicin adsorbed onto gold nanoparticles and covered by a polyelectrolyte complex layer (Articolo in rivista)

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Label
  • Sustained in vitro release and cell uptake of doxorubicin adsorbed onto gold nanoparticles and covered by a polyelectrolyte complex layer (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ijpharm.2012.08.057 (literal)
Alternative label
  • Minati L; Antonini V; Torrengo S; Dalla Serra M; Boustta M; Leclercq X; Migliaresi C; Vert M; Speranza G (2012)
    Sustained in vitro release and cell uptake of doxorubicin adsorbed onto gold nanoparticles and covered by a polyelectrolyte complex layer
    in International journal of pharmaceutics (Print); Elsevier, Amsterdam (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Minati L; Antonini V; Torrengo S; Dalla Serra M; Boustta M; Leclercq X; Migliaresi C; Vert M; Speranza G (literal)
Pagina inizio
  • 45 (literal)
Pagina fine
  • 52 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0378517312008654 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 438 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1-2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • FBK, Via Sommarive 18, Povo 38123 Trento, Italy; IBF, Consiglio Nazionale delle Ricerche, Via Sommarive 18, 38123 Trento, Italy; Department of Materials Egineering and Industrial Technologies University of Trento, Via Mesiano 77, 38123 Trento, Italy; Biotech Research Center, University of Trento, Via delle Regole 101, 38123 Trento, Italy; IBMM, UMR CNRS 5247, Research Centre for Artificial Biopolymers, University of Montpellier 1, Faculty of Pharmacy, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France (literal)
Titolo
  • Sustained in vitro release and cell uptake of doxorubicin adsorbed onto gold nanoparticles and covered by a polyelectrolyte complex layer (literal)
Abstract
  • Gold nanoparticles functionalized with doxorubicin and stabilized with multilayers of degradable polyelectrolyte were allowed to age in aqueous medium in vitro in order to show the possibility of drug release in cellular environment. The chemico-physical characteristics of the nanoparticles are reported. The observed release of doxorubicin (DOX) was pH-dependent, and it increased in acidic environment. Cell uptake of nanoparticles and drug release were monitored by laser scanning confocal microscopy. Data showed that drug-bearing nanoparticles delivered DOX into the nuclei of A549 cells, leading to pronounced cytotoxic effects to this lung tumor cells. Our results suggest that gold nanoparticles conjugated with doxorubicin could be used as a pH-triggered drug releasing carrier for tumor drug delivery. (literal)
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