http://www.cnr.it/ontology/cnr/individuo/prodotto/ID208329

Dorsoventral Differences in Intrinsic Properties in Developing CA1 Pyramidal Cells (Articolo in rivista)

Type

Label

Dorsoventral Differences in Intrinsic Properties in Developing CA1 Pyramidal Cells (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Marcelin B; Liu Z; Chen Y; Lewis AS; Becker A; McClelland S; Chetkovich DM; Migliore M; Baram TZ; Esclapez M; Bernard C (2012)
Dorsoventral Differences in Intrinsic Properties in Developing CA1 Pyramidal Cells
in The Journal of neuroscience; Society of Neuroscience, Washington (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Marcelin B; Liu Z; Chen Y; Lewis AS; Becker A; McClelland S; Chetkovich DM; Migliore M; Baram TZ; Esclapez M; Bernard C (literal)

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1106, Marseille, F-13385 France; Aix Marseille Université, Faculté de Médecine, Marseille, F-13385 France; Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Departments of Anatomy/Neurobiology and Pediatrics, University of California-Irvine, Irvine, California 92697-4475; Department of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany; Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Institute of Biophysics, National Research Council, 90416 Palermo, Italy (literal)

Titolo

Dorsoventral Differences in Intrinsic Properties in Developing CA1 Pyramidal Cells (literal)

Abstract

The dorsoventral and developmental gradients of entorhinal layer II cell grid properties correlate with their resonance properties and with their hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel current characteristics. We investigated whether such correlation existed in rat hippocampal CA1 pyramidal cells, where place fields also show spatial and temporal gradients. Resonance was absent during the first postnatal week, and emerged during the second week. Resonance was stronger in dorsal than ventral cells, in accord with HCN current properties. Resonance responded to cAMP in ventral but not in dorsal cells. The dorsoventral distribution of HCN1 and HCN2 subunits and of the auxiliary protein tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) could account for these differences between dorsal and ventral cells. The analogous distribution of the intrinsic properties of entorhinal stellate and hippocampal cells suggests the existence of general rules of organization among structures that process complementary features of the environment. (literal)

Editore