Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance training (Articolo in rivista)

Type
Label
  • Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance training (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1152/japplphysiol.00883 (literal)
Alternative label
  • Desy Salvadego; Rossana Domenis; Stefano Lazzer; Simone Porcelli; Jörn Rittweger; Giovanna Rizzo; Irene Mavelli; Bostjan ?imuni?; Rado Pi?ot; Bruno Grassi. (2013)
    Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance training
    in Journal of applied physiology (1985 Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Desy Salvadego; Rossana Domenis; Stefano Lazzer; Simone Porcelli; Jörn Rittweger; Giovanna Rizzo; Irene Mavelli; Bostjan ?imuni?; Rado Pi?ot; Bruno Grassi. (literal)
Pagina inizio
  • 1527 (literal)
Pagina fine
  • 1535 (literal)
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  • 114 (literal)
Rivista
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  • 11 (literal)
Note
  • PubMe (literal)
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  • Department of Medical and Biological Sciences, University of Udine, Udine, Italy. Institute of Bioimaging and Molecular Physiology, National Research Council, Milan, Italy. Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany. Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan. University, Manchester, United Kingdom. Institute for Kinesiology Research, Science and Research Center, University of Primorska, Koper, Slovenia. (literal)
Titolo
  • Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance training (literal)
Abstract
  • Oxidative function during exercise was evaluated in 11 young athletes with marked skeletal muscle hypertrophy induced by long-term resistance training (RTA, body mass 102.6±7.3 kg, mean±SD) and 11 controls (CTRL, body mass 77.8±6.0). Pulmonary O2 uptake (V'O2) and vastus lateralis muscle fractional O2 extraction (by near-infrared spectroscopy) were determined during an incremental cycle ergometer (CE) and one-leg knee-extension (KE) exercise. Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in permeabilized vastus lateralis fibers obtained by biopsy. Quadriceps femoris muscle cross sectional area, volume (determined by magnetic resonance imaging) and strength were greater in RTA vs. CTRL (by ~40%, ~33% and ~20%, respectively). V'O2peak during CE was higher in RTA vs. CTRL (4.05±0.64 L min-1 vs. 3.56±0.30); no difference between groups was observed during KE. The O2 cost of CE exercise was not different between groups. When divided per muscle mass (for CE) or quadriceps muscle mass (for KE) V'O2peak was lower (by 15-20%) in RTA vs. CTRL. Vastus lateralis fractional O2 extraction was lower in RTA vs. CTRL at all work rates, both during CE and KE. RTA had higher ADP-stimulated mitochondrial respiration (56.7±23.7 pmolO2os-1omg-1 ww) vs. CTRL (35.7±10.2), and a tighter coupling of oxidative phosphorylation. In RTA the greater muscle mass and maximal force, and the enhanced mitochondrial respiration seem to compensate for the hypertrophy-induced impaired peripheral O2 diffusion. The net results are an enhanced whole body oxidative function at peak exercise, and unchanged efficiency and O2 cost at submaximal exercise, despite a much greater body mass. (literal)
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