18F-Fluoride-based Molecular Calcium Deposition as biomarker of early and ongoing molecular calcification in the vascular walls in low, intermediate, and high cardiovascular risk subgroups. (Abstract in rivista)

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  • 18F-Fluoride-based Molecular Calcium Deposition as biomarker of early and ongoing molecular calcification in the vascular walls in low, intermediate, and high cardiovascular risk subgroups. (Abstract in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • F. Fiz; L. Picori; A. Piccardo; M. Massollo; E. Pestarino; Cecilia Marini; G. Ghigliotti; M. Cabria; A. Democrito; A. Lasaponara; A. Alavi; Gianmario Sambuceti; S. Morbelli. (2012)
    18F-Fluoride-based Molecular Calcium Deposition as biomarker of early and ongoing molecular calcification in the vascular walls in low, intermediate, and high cardiovascular risk subgroups.
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • F. Fiz; L. Picori; A. Piccardo; M. Massollo; E. Pestarino; Cecilia Marini; G. Ghigliotti; M. Cabria; A. Democrito; A. Lasaponara; A. Alavi; Gianmario Sambuceti; S. Morbelli. (literal)
Pagina inizio
  • S251 (literal)
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  • 39 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • Suppl-2 (literal)
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  • Nuclear Medicine Unit, San Martino Hospital, Genoa, Italy. Nuclear Medicine Unit, Galliera Hospital, Genoa, Italy. Institute of Molecular Bioimaging and Physiology, CNR, Genoa, Italy. Cardiology and Laboratory of Cardiovascular Biology, San Martino Hospital, Genoa, Italy. Division of Nuclear Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA (USA). (literal)
Titolo
  • 18F-Fluoride-based Molecular Calcium Deposition as biomarker of early and ongoing molecular calcification in the vascular walls in low, intermediate, and high cardiovascular risk subgroups. (literal)
Abstract
  • Aim: To evaluate the potential of 18F-Fluoride PET in the detection of early and ongoing molecular calcification within the vascular walls. Methods: The present study included 63 oncologic patients (14 males, mean age 61.3±8.2 range 27- 81) who underwent 18F-Fluoride PET/CT imaging in the course of follow up for either breast or prostate cancer. Soon before imaging, all patients were administered with a questionnaire for cardiovascular risk stratification according to the Framingham model. The whole study group was thus subdivided into three risk categories: low (<10%, n=18), intermediate (10% to 20%, n=31), and high (>20%, n=14). In each patient, volumetric regions of interest (ROI) were drawn on three aortic segments (arch, thoracic and abdominal aorta), subclavian, carotid, iliac and femoral arteries, respectively. In these regions, average 18F-fluoride uptake was measured and normalized for the blood-pool radioactivity concentration to obtain target to background SUV ratio (SUVR).These same regions were used to estimate arterial calcium load (CL) at the co-registered CT images. Finally, Calcification Score (GMCS) for each patient was generated taking into account mean SUV of the entire heart and heart-volume on the CT-scan as previously validated (1). Results: The 14 high-risk patients showed the highest values of CL, average SUVR and GMCS (p<0.01, p<0.001, p<0.03 respectively). However, CL and GMCS were similar in patients at intermediate or low risk. On the contrary, these two different risk profiles were paralleled by significant difference in SUVR (2.9± 0.6 1.8±0.4 in intermediate and low risk patients, respectively, p<0.05). Finally, within each group calcified segments showed similar SUVR with respect to non calcified arterial walls. Conclusion: The present study is consistent with the notion that PET/CT imaging of fluoride uptake can identify early, molecular, stages of arterial calcification. This phenomenon precedes the morphological evidence of calcium burden at conventional CT imaging. In particular, the similar SUVR in calcified and non calcified regions fits with the concept that arterial calcification is an active process in which small calcium crystals appear early in the course of atherosclerosis and only late aggregate to large hydroxyapatite crystals. Further studies are needed to validate the role of this promising technique in the management of patients with suspected atherosclerosis. (Ref. 1.Beheshti M et al Detection and global quantification of cardiovascular molecular calcification by fluoro18-fluoride positron emission tomography/computed tomography--a novel concept. Hell J Nucl Med. 2011 May-Aug;14(2):114-20). (literal)
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