Impairing effect of amphetamine and concomitant ionotropic glutamate receptors blockade in the ventral striatum on spatial learning in mice (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Impairing effect of amphetamine and concomitant ionotropic glutamate receptors blockade in the ventral striatum on spatial learning in mice (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00213-013-2989-9 (literal)

Alternative label

• Roberto Coccurello 1,2; Alberto Oliverio 1,2,3; Andrea Mele 1,2,3 (2013)
  Impairing effect of amphetamine and concomitant ionotropic glutamate receptors blockade in the ventral striatum on spatial learning in mice
  in Psychopharmacology (Berl).
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Roberto Coccurello 1,2; Alberto Oliverio 1,2,3; Andrea Mele 1,2,3 (literal)

Pagina inizio

• 651 (literal)

Pagina fine

• 660 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• 2013 Feb 5. [Epub ahead of print] (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 227 (literal)

Rivista

• Psychopharmacology (Berl). (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Department of Biology and Biotechnology, Università degli Studi di Roma \"La Sapienza\", P.le Aldo Moro 5, 00185 Rome, Italy. 2 C.N.R. National Research Council of Italy, Cell Biology and Neurobiology Institute (IBCN), Rome, Italy. 3 Centro di Ricerca in Neurobiologia D. Bovet, Università degli Studi di Roma \"La Sapienza\", P.le Aldo Moro 5, 00185 Rome, Italy. (literal)

Titolo

• Impairing effect of amphetamine and concomitant ionotropic glutamate receptors blockade in the ventral striatum on spatial learning in mice (literal)

Abstract

• RATIONALE: Accumulating evidence supports the involvement of the ventral striatum (VS) in spatial information processing. The multiple cortical glutamatergic and mesolimbic dopaminergic (DAergic) afferences on the same neurons in the ventral striatum provide the neuroanatomical substrate for glutamate and dopamine functional interaction. However, there is little evidence in the literature on how this interaction affects the ability to encode spatial information. OBJECTIVE: First, we evaluated the effect of intra-VS bilateral infusion of different doses of amphetamine (0.3, 0.75, and 1.5 ?g/side) on the ability to detect spatial novelty in mice. Next, we examined the impact produced on the same abilities by intra-VS infusion of ineffective doses of amphetamine (0.3 ?g/side) in association with N-methyl-D-aspartate (NMDA) (3.125 ng/side) or ?-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) (0.25 ng/side) receptor antagonist. RESULTS: The results show that infusion of amphetamine impairs detection of spatial novelty, affecting also exploratory activity and marginally the detection of nonspatial novelty. In contrast, an association of subthreshold doses of amphetamine with NMDA or AMPA receptor antagonists exerted a selective effect on reactivity to a spatial change. CONCLUSIONS: These findings demonstrate that enhanced DAergic activity in the VS enhances glutamate receptor antagonist-induced impairment in learning and memory. (literal)

Prodotto di

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Autore CNR

• ALBERTO OLIVERIO (Persona)
• ROBERTO COCCURELLO (Persona)
• ANDREA MELE (Unità di personale esterno)

Incoming links:

Autore CNR di

• ALBERTO OLIVERIO (Persona)
• ANDREA MELE (Unità di personale esterno)
• ROBERTO COCCURELLO (Persona)

Prodotto

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Psychopharmacology (Berl). (Rivista)