Plasma selenoproteins concentrations in type 2 diabetes mellitus - A pilot study (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Plasma selenoproteins concentrations in type 2 diabetes mellitus - A pilot study (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Roman, M.; Lapolla, A.; Jitaru, P.; Sechi, A.; Cosma, C.; Cozzi, G.; Cescon, P.; Barbante, C. (2010)
  Plasma selenoproteins concentrations in type 2 diabetes mellitus - A pilot study
  in Translational research (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Roman, M.; Lapolla, A.; Jitaru, P.; Sechi, A.; Cosma, C.; Cozzi, G.; Cescon, P.; Barbante, C. (literal)

Pagina inizio

• 242 (literal)

Pagina fine

• 250 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 156 (literal)

Rivista

• Translational research (Rivista)

Note

• Scopus (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Environmental Sciences, University of Venice Ca' Foscari, Dorsoduro 2137, 30123 Venice, Italy; Department of Medical and Surgical Sciences, University of Padova, Padova, Italy; Institute for the Dynamics of Environmental Processes (IDPA-CNR), Venice, Italy; Institut Polytechnique LaSalle Beauvais, Département des Sciences et Techniques Agro-Industrielles, Beauvais Cedex, France (literal)

Titolo

• Plasma selenoproteins concentrations in type 2 diabetes mellitus - A pilot study (literal)

Abstract

• The association between the concentration/activity of selenium/selenoproteins in plasma and type 2 diabetes mellitus is still a matter of debate. This cross-sectional pilot study evaluates whether patients with diabetes present a different plasma selenoproteins status than a healthy control group and examines whether the introduction of clinical parameters allows the detection of correlations and further grouping criteria. For this purpose, the levels of plasma glutathione peroxidase (GPx), selenoprotein P (SelP), and seleno-albumin (SeAlb) present in 40 patients affected by type 2 diabetes mellitus were determined simultaneously and accurately by a newly developed analytical method. The results show that patients with diabetes demonstrate significantly lower levels of GPx and SeAlb with respect to healthy subjects (11 +/- 3 ng/mL and 9 +/- 2 ng/mL vs 18 +/- 8 ng/mL and 11 +/- 2 ng/mL, respectively). Significant negative correlations were revealed among GPx, SeAlb, and clinical parameters including fasting plasma glucose, hemoglobin A1c, and the albumin-to-creatinine ratio. Our findings suggest an association between the individual selenoproteins concentration and the presence of diabetes, including associated clinical parameters. It currently cannot be ascertained whether the altered selenoproteins status is a consequence or a causative factor for diabetes. This study demonstrates the potential of a method for individual selenoproteins determination for investigating the biochemical relationship between selenium and diabetes (literal)

Prodotto di

• Microinquinanti organici ed inorganici in aree a diversa antropizzazione (TA.P03.011.001) (Modulo)
• Istituto per la dinamica dei processi ambientali (IDPA) (Istituto)

Autore CNR

• PETRU JITARU (Unità di personale esterno)
• PAOLO CESCON (Unità di personale esterno)
• GIULIO COZZI (Unità di personale interno)
• CARLO BARBANTE (Persona)

Incoming links:

Prodotto

• Istituto per la dinamica dei processi ambientali (IDPA) (Istituto)
• Microinquinanti organici ed inorganici in aree a diversa antropizzazione (TA.P03.011.001) (Modulo)

Autore CNR di

• PETRU JITARU (Unità di personale esterno)
• CARLO BARBANTE (Persona)
• PAOLO CESCON (Unità di personale esterno)
• GIULIO COZZI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Translational research (Rivista)