Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00213-012-2925-4 (literal)

Alternative label

• F. Managò 1; S. Lopez 2; A. Oliverio1,3; M. Amalric 2; A. Mele 1,2; E. De Leonibus 1,4 (2013)
  Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice
  in Psychopharmacology (Berlin. Internet)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• F. Managò 1; S. Lopez 2; A. Oliverio1,3; M. Amalric 2; A. Mele 1,2; E. De Leonibus 1,4 (literal)

Pagina inizio

• 541 (literal)

Pagina fine

• 550 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• 2012 Nov 29. [Epub ahead of print]. - Rivista pubblicata anche in ed. cartacea (ISSN 0033-3158) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 26 (literal)

Rivista

• Psychopharmacology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Dipartimento di Biologia e Biotecnologie \"C. Darwin\", Università degli Studi di Roma \"La Sapienza\",Rome, Italy. 2 Laboratoire de Neurobiologie de la Cognition,Universités Aix-Marseille, CNRS UMR6155,Marseille, France. 3 Istituto di Biologia Cellulare e Neurobiologia (CNR), Rome, Italy. 4 Institute of Genetics and Biophysics (IGB),National Research Council (CNR),Via Pietro Catellino 111, CNR,Naples, Italy. (literal)

Titolo

• Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice (literal)

Abstract

• RATIONALE: Metabotropic glutamate mGlu receptors 5 (mGluR5) receptors are abundant in corticolimbic circuitry where they modulate glutamate and dopamine signal transduction. OBJECTIVES: In this study, we explored the hypothesis that mGluR5 antagonist, (2-methyl-6-(phenylethynyl)pyridine hydrochloride) (MPEP), facilitates dopamine-dependent effects on memory and motor functions. METHODS: To this aim, we examined the effects of different doses (from 0 to 24 mg/kg) of the mGluR5 antagonist, MPEP, on the modulation of amphetamine-dependent behaviors, namely passive avoidance, locomotor activity, and rotation behavior in intact and dopamine-depleted CD1 male mice. RESULTS: We demonstrated that a low dose (3 mg/kg) of MPEP, which is void of behavioral effects on its own, facilitates amphetamine-induced effects independently on the behavior measured both in naïve and in dopamine-lesioned mice; this synergistic effect is lost when higher doses of MPEP are used. CONCLUSION: The results are discussed in terms of possible balance between dopamine and glutamate activity in regulating the proper fine tuning of information processing. (literal)

Prodotto di

• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• ANDREA MELE (Unità di personale esterno)
• ELVIRA DE LEONIBUS (Persona)
• ALBERTO OLIVERIO (Persona)

Insieme di parole chiave

• Parole chiave di "Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)

Autore CNR di

• ALBERTO OLIVERIO (Persona)
• ANDREA MELE (Unità di personale esterno)
• ELVIRA DE LEONIBUS (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Psychopharmacology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice" (Insieme di parole chiave)