CREB selectively controls learning-induced structural remodeling of neurons (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• CREB selectively controls learning-induced structural remodeling of neurons (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1101/lm.025817.112 (literal)

Alternative label

• Middei Silvia1,2,10; Spalloni Alida3; Longone Patrizia3; Pittenger Christopher4; O'Mara Shane M.7; Marie Hélène8;9; Ammassari-Teule Martine1,2,10 (2012)
  CREB selectively controls learning-induced structural remodeling of neurons
  in Learning & memory (Cold Spring Harbor N.Y. Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Middei Silvia1,2,10; Spalloni Alida3; Longone Patrizia3; Pittenger Christopher4; O'Mara Shane M.7; Marie Hélène8;9; Ammassari-Teule Martine1,2,10 (literal)

Pagina inizio

• 330 (literal)

Pagina fine

• 336 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 19 (literal)

Rivista

• Learning & memory (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 CNR-National Research Council, Rome 00143, Italy- 2 Experimental Neurology Unit, Santa Lucia Foundation, Rome 00143, Italy. 3 Molecular Neurobiology Unit, Santa Lucia Foundation, Rome 00143, Italy. 4 Department of Psychiatry and Psychology, Yale University, New Haven, Connecticut 06508, USA. 5 Yale Child Study Center, and Yale University, New Haven, Connecticut 06508, USA. 6 Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06508, USA. 7 Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland. 8 Laboratory of Molecular Mechanisms of Synaptic Plasticity, European Brain Research Institute, Rome 00143, Italy. (literal)

Titolo

• CREB selectively controls learning-induced structural remodeling of neurons (literal)

Abstract

• The modulation of synaptic strength associated with learning is post-synaptically regulated by changes in density and shape of dendritic spines. The transcription factor CREB (cAMP response element binding protein) is required for memory formation and in vitro dendritic spine rearrangements, but its role in learning-induced remodeling of neurons remains elusive. Using transgenic mice conditionally expressing a dominant-negative CREB (CREBS133A: mCREB) mutant, we found that inhibiting CREB function does not alter spine density, spine morphology, and levels of polymerized actin in naive CA1 neurons. CREB inhibition, however, impaired contextual fear conditioning and produced a learning-induced collapse of spines associated with a blockade of learning-dependent increase in actin polymerization. Blocking mCREB expression with doxycycline rescued memory and restored a normal pattern of learning-induced spines, demonstrating that CREB controls structural adaptations of neurons selectively involved in memory formation. (literal)

Prodotto di

• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)

Autore CNR

• ANNE MARIE TEULE (Persona)
• SILVIA MIDDEI (Unità di personale esterno)

Incoming links:

Autore CNR di

• ANNE MARIE TEULE (Persona)
• SILVIA MIDDEI (Unità di personale esterno)

Prodotto

• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Learning & memory (Rivista)