Kidins220/ARMS Is a Novel Modulator of Short-Term Synaptic Plasticity in Hippocampal GABAergic Neurons (Articolo in rivista)

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  • Kidins220/ARMS Is a Novel Modulator of Short-Term Synaptic Plasticity in Hippocampal GABAergic Neurons (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1371/journal.pone.0035785 (literal)
Alternative label
  • Scholz-Starke J; Cesca F; Schiavo G; Benfenati F; Baldelli P (2012)
    Kidins220/ARMS Is a Novel Modulator of Short-Term Synaptic Plasticity in Hippocampal GABAergic Neurons
    in PloS one; PUBLIC LIBRARY OF SCIENCE, SAN FRANCISCO (Stati Uniti d'America)
    (literal)
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  • Scholz-Starke J; Cesca F; Schiavo G; Benfenati F; Baldelli P (literal)
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  • e35785 (literal)
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  • http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0035785 (literal)
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  • 7 (literal)
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  • 4 (literal)
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  • Ist Italiano Tecnol, Dept Neurosci & Brain Technol, Genoa, Italy; Canc Res UK London Res Inst, Mol Neuropathobiol Lab, London, England; Univ Genoa, Dept Expt Med, Genoa, Italy; Natl Inst Neurosci, Genoa, Italy (literal)
Titolo
  • Kidins220/ARMS Is a Novel Modulator of Short-Term Synaptic Plasticity in Hippocampal GABAergic Neurons (literal)
Abstract
  • Kidins220 (Kinase D interacting substrate of 220 kDa)/ARMS (Ankyrin Repeat-rich Membrane Spanning) is a scaffold protein highly expressed in the nervous system. Previous work on neurons with altered Kidins220/ARMS expression suggested that this protein plays multiple roles in synaptic function. In this study, we analyzed the effects of Kidins220/ARMS ablation on basal synaptic transmission and on a variety of short-term plasticity paradigms in both excitatory and inhibitory synapses using a recently described Kidins220 full knockout mouse. Hippocampal neuronal cultures prepared from embryonic Kidins220-/- (KO) and wild type (WT) littermates were used for whole-cell patch-clamp recordings of spontaneous and evoked synaptic activity. Whereas glutamatergic AMPA receptor-mediated responses were not significantly affected in KO neurons, specific differences were detected in evoked GABAergic transmission. The recovery from synaptic depression of inhibitory post-synaptic currents in WT cells showed biphasic kinetics, both in response to paired-pulse and long-lasting train stimulation, while in KO cells the respective slow components were strongly reduced. We demonstrate that the slow recovery from synaptic depression in WT cells is caused by a transient reduction of the vesicle release probability, which is absent in KO neurons. These results suggest that Kidins220/ARMS is not essential for basal synaptic transmission and various forms of short-term plasticity, but instead plays a novel role in the mechanisms regulating the recovery of synaptic strength in GABAergic synapses. (literal)
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