Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation. (Articolo in rivista)

Type
Label
  • Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3109/10520290903149612 (literal)
Alternative label
  • Zingariello M, Fabucci ME, Bosco D, Migliaccio AR, Martelli F, Rana RA, Zetterberg E. (2010)
    Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation.
    in Biotechnic & histochemistry; Informa Healthcare, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Zingariello M, Fabucci ME, Bosco D, Migliaccio AR, Martelli F, Rana RA, Zetterberg E. (literal)
Pagina inizio
  • 157 (literal)
Pagina fine
  • 170 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 85 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 14 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy Mt Sinai Sch Med, Dept Hematol & Oncol, New York, NY USA Univ G dAnnunzio, Dept Biomorphol, Chieti, Italy IGM-CNR Chieti (literal)
Titolo
  • Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation. (literal)
Abstract
  • An important step in megakaryocyte maturation is the appropriate assembly of at least two distinct subsets of alpha-granules. The mechanism that sorts the alpha-granule components into distinct structures and mediates their release in response to specific stimuli is now emerging. P-selectin and von Willebrand factor are two proteins present in the alpha-granules that recognize P-selectin glycoprotein ligand on neutrophils and collagen in the subendothelial matrix. These proteins may play an important role in determining the differential release of the alpha-granule contents in response to external stimuli. If P-selectin and von Willebrand factor are localized in the same or different alpha-granules is not known. To clarify this question, we analyzed by immunoelectron microscopy the localization of von Willebrand factor and P-selectin during the maturation of wild-type and Gata1
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