http://www.cnr.it/ontology/cnr/individuo/prodotto/ID199668
Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation. (Articolo in rivista)
- Type
- Label
- Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation. (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.3109/10520290903149612 (literal)
- Alternative label
Zingariello M, Fabucci ME, Bosco D, Migliaccio AR, Martelli F, Rana RA, Zetterberg E. (2010)
Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation.
in Biotechnic & histochemistry; Informa Healthcare, New York (Stati Uniti d'America)
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- Zingariello M, Fabucci ME, Bosco D, Migliaccio AR, Martelli F, Rana RA, Zetterberg E. (literal)
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- Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy
Mt Sinai Sch Med, Dept Hematol & Oncol, New York, NY USA
Univ G dAnnunzio, Dept Biomorphol, Chieti, Italy
IGM-CNR Chieti (literal)
- Titolo
- Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation. (literal)
- Abstract
- An important step in megakaryocyte maturation is the appropriate assembly of at least two distinct subsets of alpha-granules. The mechanism that sorts the alpha-granule components into distinct structures and mediates their release in response to specific stimuli is now emerging. P-selectin and von Willebrand factor are two proteins present in the alpha-granules that recognize P-selectin glycoprotein ligand on neutrophils and collagen in the subendothelial matrix. These proteins may play an important role in determining the differential release of the alpha-granule contents in response to external stimuli. If P-selectin and von Willebrand factor are localized in the same or different alpha-granules is not known. To clarify this question, we analyzed by immunoelectron microscopy the localization of von Willebrand factor and P-selectin during the maturation of wild-type and Gata1
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