Self-assembly of short DNA duplexes: from a coarse-grained model to experiments through a theoretical link (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Self-assembly of short DNA duplexes: from a coarse-grained model to experiments through a theoretical link (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/c2sm25845e (literal)

Alternative label

• Cristiano De Michele (a); Lorenzo Rovigatti (b); Tommaso Bellini (c); Francesco Sciortino (d) (2012)
  Self-assembly of short DNA duplexes: from a coarse-grained model to experiments through a theoretical link
  in Soft matter (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cristiano De Michele (a); Lorenzo Rovigatti (b); Tommaso Bellini (c); Francesco Sciortino (d) (literal)

Pagina inizio

• 8388 (literal)

Pagina fine

• 8398 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://pubs.rsc.org/en/content/articlehtml/2012/sm/c2sm25845e (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 8 (literal)

Rivista

• Soft matter (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 32 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (a) Dipartimento di Fisica, \"Sapienza\" Università di Roma, P.le A. Moro 2, Roma, I-00185, Italy. E-mail: cristiano.demichele@roma1.infn.it; Fax: +39 06463158; Tel: +39 0649913524 (b) Dipartimento di Fisica, \"Sapienza\" Università di Roma, P.le A. Moro 2, Roma, I-00185, Italy (c) Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università di Milano, I-20122 Milano, Italy (d) Dipartimento di Fisica, and CNR-ISC, \"Sapienza\" Università di Roma, P.le A. Moro 2, 00185 Roma, Italy (literal)

Titolo

• Self-assembly of short DNA duplexes: from a coarse-grained model to experiments through a theoretical link (literal)

Abstract

• Short blunt-ended DNA duplexes comprising 6 to 20 base pairs self-assemble into polydisperse semi-flexible chains due to hydrophobic stacking interactions between terminal base pairs. Above a critical concentration, which depends on temperature and duplex length, such chains order into liquid crystal phases. Here, we investigate the self-assembly of such double-helical duplexes with a combined numerical and theoretical approach. We simulate the bulk system employing the coarse-grained DNA model recently proposed by Ouldridge et al. [J. Chem. Phys., 2011, 134, 08501]. Then we evaluate the input quantities for the theoretical framework directly from the DNA model. The resulting parameter-free theoretical predictions provide an accurate description of the simulation results in the isotropic phase and theoretical values for the isotropic-nematic phase boundaries which are in line with experimental findings. In addition, the developed theoretical framework makes it possible to provide a route to estimate the stacking free energy. (literal)

Prodotto di

• Materia soffice: Self Assembly, Clustering, Arresto Strutturale (MD.P02.015.001) (Modulo)

Autore CNR

• FRANCESCO SCIORTINO (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Self-assembly of short DNA duplexes: from a coarse-grained model to experiments through a theoretical link" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FRANCESCO SCIORTINO (Unità di personale esterno)

Prodotto

• Materia soffice: Self Assembly, Clustering, Arresto Strutturale (MD.P02.015.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Soft matter (Rivista)

Insieme di parole chiave di

• Keywords of "Self-assembly of short DNA duplexes: from a coarse-grained model to experiments through a theoretical link" (Insieme di parole chiave)