Mitochondria and ALS: Implications from novel genes and pathways (Articolo in rivista)

Type
Label
  • Mitochondria and ALS: Implications from novel genes and pathways (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cozzolino M, Ferri A, Valle C, Carrì MT. (2012)
    Mitochondria and ALS: Implications from novel genes and pathways
    in Molecular and cellular neurosciences (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cozzolino M, Ferri A, Valle C, Carrì MT. (literal)
Rivista
Note
  • PubMed (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute for Translational Pharmacology, CNR, Rome, Italy Fondazione Santa Lucia IRCCS, Rome, Italy Institute for Cell Biology and Neurobiology, CNR, Rome, Italy Department of Biology, University of Rome Tor Vergata, Rome, Italy (literal)
Titolo
  • Mitochondria and ALS: Implications from novel genes and pathways (literal)
Abstract
  • Evidence from patients with sporadic and familiar amyotrophic lateral sclerosis (ALS) and from models based on the overexpression of mutant SOD1 found in a small subset of patients, clearly point to mitochondrial damage as a relevant facet of this neurodegenerative condition. In this mini-review we provide a brief update on the subject in the light of newly discovered genes (such as TDP-43 and FUS/TLS) associated to familial ALS and of a deeper knowledge of the mechanisms of derangement of mitochondria. This article is part of a Special Issue entitled 'Mitochondrial function'. (literal)
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