Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/acel.12034 (literal)

Alternative label

• Germana Falcone 1-2; Alessia Mazzola 1; Flavia Michelini 1; Gianluca Bossi 3; Federica Censi 4; Maria G. Biferi 1; Luisa Minghetti 1; Giovanna Floridia 4; Maurizio Federico 5; Antonio Musio 6-7; Marco Crescenzi 1 (2013)
  Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence
  in Aging cell (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Germana Falcone 1-2; Alessia Mazzola 1; Flavia Michelini 1; Gianluca Bossi 3; Federica Censi 4; Maria G. Biferi 1; Luisa Minghetti 1; Giovanna Floridia 4; Maurizio Federico 5; Antonio Musio 6-7; Marco Crescenzi 1 (literal)

Pagina inizio

• 312 (literal)

Pagina fine

• 315 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Epub 2012 Dec 25 http://www.deepdyve.com/lp/wiley/cytogenetic-analysis-of-human-cells-reveals-specific-patterns-of-dna-t44vhN2d2j (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 12 (literal)

Rivista

• Aging cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Department of Cell Biology and Neurosciences, National Institute of Health, Rome, Italy. 2 Institute of Cell Biology and Neurobiology, National Research Council, Monterotondo (Rome), Italy. 3 Department of Molecular Oncology, Regina Elena Cancer Institute, Rome, Italy. 4 National Centre for Rare Diseases, National Institute of Health, Rome, Italy. 5 National AIDS Centre, National Institute of Health, Rome, Italy. 6 Institute of Genetic and Biomedical Research, National Research Council, Pisa, Italy. 7 Istituto Toscano Tumori, Florence, Italy. (literal)

Titolo

• Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence (literal)

Abstract

• Senescence is thought to be triggered by DNA damage, usually indirectly assessed as activation of the DNA damage response (DDR), but direct surveys of genetic damage are lacking. Here, we mitotically reactivate senescent human fibroblasts to evaluate their cytogenetic damage. We show that replicative senescence is generally characterized by telomeric fusions. However, both telomeric and extratelomeric aberrations are prevented by hTERT, indicating that even non-telomeric damage descends from the lack of telomerase. Compared with replicative senescent cells, oncogene-induced senescent fibroblasts display significantly higher levels of DNA damage, depicting how oncogene activation can catalyze the generation of further, potentially tumorigenic, genetic damage. (literal)

Prodotto di

• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)
• ex SV.P15.004.001 / Trasduzione del segnale e malattie multifattoriali (SV.P15.004.002) (Modulo)
• MEDICINA TRASLAZIONALE: RUOLO DELLA COESINA NELLE PATOLOGIE GENETICHE UMANE E IN ONCOLOGIA (ME.P03.017.001) (Modulo)

Autore CNR

• GERMANA FALCONE (Unità di personale interno)
• ANTONIO MUSIO (Persona)

Insieme di parole chiave

• Parole chiave di "Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANTONIO MUSIO (Persona)
• GERMANA FALCONE (Unità di personale interno)

Prodotto

• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)
• MEDICINA TRASLAZIONALE: RUOLO DELLA COESINA NELLE PATOLOGIE GENETICHE UMANE E IN ONCOLOGIA (ME.P03.017.001) (Modulo)
• ex SV.P15.004.001 / Trasduzione del segnale e malattie multifattoriali (SV.P15.004.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Aging cell (Rivista)

Insieme di parole chiave di

• Parole chiave di "Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence" (Insieme di parole chiave)