Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin. (Articolo in rivista)

Type
Label
  • Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.1204017109 (literal)
Alternative label
  • Guardiola O, Lafuste P, Brunelli S, Iaconis S, Touvier T, Mourikis P, De Bock K, Lonardo E, Andolfi G, Bouché A, Liguori GL, Shen MM, Tajbakhsh S, Cossu G, Carmeliet P, Minchiotti G. (2012)
    Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Guardiola O, Lafuste P, Brunelli S, Iaconis S, Touvier T, Mourikis P, De Bock K, Lonardo E, Andolfi G, Bouché A, Liguori GL, Shen MM, Tajbakhsh S, Cossu G, Carmeliet P, Minchiotti G. (literal)
Pagina inizio
  • E2331 (literal)
Pagina fine
  • E2340 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 109(47) (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • aStem Cell Fate Laboratory, Institute of Genetics and Biophysics \"Adriano Buzzati-Traverso,\" Consiglio Nazionale delle Ricerche, 80131 Naples, Italy; bInstitute of Genetics and Biophysics \"Adriano Buzzati-Traverso,\" Consiglio Nazionale delle Ricerche, 80131 Naples, Italy; cLaboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Flemish Institute of Biotechnology, 3000 Leuven, Belgium; dLaboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Department of Oncology, University of Leuven, 3000 Leuven, Belgium; eInstitut National de la Santé et de la Recherche Médicale, U955, Team 10 \"Cell Interactions in the Neuromuscular System,\" University Paris Est Creteil, F-94000 Creteil, France; fDivision of Regenerative Medicine, San Raffaele Scientific Institute, 20132 Milan, Italy; gDepartment of Experimental Medicine, University of Milano-Bicocca, 20052 Monza, Italy; hEugenio Medea Scientific Institute, 23842 Bosisio Parini, Italy; iStem Cells and Development Unit, Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Recherche Associée, 2578 Paris, France; jDepartments of Medicine and Genetics & Development, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032; and kDepartment of Cell and Developmental Biology, University College London, London WC1E 6DE, United Kingdom (literal)
Titolo
  • Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin. (literal)
Abstract
  • Skeletal muscle regeneration mainly depends on satellite cells, a population of resident muscle stem cells. However, our understanding of the molecular mechanisms underlying satellite cell activation is still largely undefined. Here, we show that Cripto, a regulator of early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression toward the myogenic lineage. Conditional inactivation of cripto in adult satellite cells compromises skeletal muscle regeneration, whereas gain of function of Cripto accelerates regeneration, leading to muscle hypertrophy. Moreover, we provide evidence that Cripto modulates myogenic cell determination and promotes proliferation by antagonizing the TGF-? ligand myostatin. Our data provide unique insights into the molecular and cellular basis of Cripto activity in skeletal muscle regeneration and raise previously undescribed implications for stem cell biology and regenerative medicine. (literal)
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