A new dinuclear platinum complex with a nitrogen-containing geminal bisphosphonate as potential anticancer compound specifically targeted to bone tissues (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A new dinuclear platinum complex with a nitrogen-containing geminal bisphosphonate as potential anticancer compound specifically targeted to bone tissues (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jinorgbio.2008.07.008 (literal)

Alternative label

• Margiotta N. 1, Capitelli F. 2, Ostuni R. 1, Natile G. 1 (2008)
  A new dinuclear platinum complex with a nitrogen-containing geminal bisphosphonate as potential anticancer compound specifically targeted to bone tissues
  in Journal of inorganic biochemistry; Elsevier Science Inc., New York (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Margiotta N. 1, Capitelli F. 2, Ostuni R. 1, Natile G. 1 (literal)

Pagina inizio

• 2078 (literal)

Pagina fine

• 2086 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 102 (literal)

Rivista

• Journal of inorganic biochemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1- Univ. di Bari, Dip. Farmaco-Chimico 2- CNR-IC, Sede di Bari (literal)

Titolo

• A new dinuclear platinum complex with a nitrogen-containing geminal bisphosphonate as potential anticancer compound specifically targeted to bone tissues (literal)

Abstract

• The paper describes the synthesis and characterization of a new platinum dinuclear complex (2) bearing a nitrogen-containing geminal bisphosphonate (NBP, 1), structurally related to the commercial drug risedronate. NBPs themselves have shown in quite a few cases to be endowed with anticancer activity, therefore the new platinum complex has two potential antitumor moieties (the NBP ligand and the platinum residue) and could have high affinity for bone tumors or metastases (due to the presence of NBP). The free bisphosphonate (1) has been crystallized by a sol-gel method and characterized by X-ray diffraction analysis. The platinum complex (2) has been found to have a dinuclear structure with the bisphosphonate bridging two platinum moieties in a W conformation. (C) 2008 Elsevier Inc. All rights reserved. (literal)

Editore

• Elsevier Science Inc. (Editore)

Prodotto di

• Institute of Crystallography (IC) (Istituto)
• Sviluppo e Applicazioni di Metodi Cristallografici (PM.P06.002.001) (Modulo)

Autore CNR

• FRANCESCO CAPITELLI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "A new dinuclear platinum complex with a nitrogen-containing geminal bisphosphonate as potential anticancer compound specifically targeted to bone tissues" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of Crystallography (IC) (Istituto)
• Sviluppo e Applicazioni di Metodi Cristallografici (PM.P06.002.001) (Modulo)

Autore CNR di

• FRANCESCO CAPITELLI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of inorganic biochemistry (Rivista)

Editore di

• Elsevier Science Inc. (Editore)

Insieme di parole chiave di

• Keywords of "A new dinuclear platinum complex with a nitrogen-containing geminal bisphosphonate as potential anticancer compound specifically targeted to bone tissues" (Insieme di parole chiave)